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An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications.
Maccari R, Del Corso A, Paoli P, Adornato I, Lori G, Balestri F, Cappiello M, Naß A, Wolber G, Ottanà R. Maccari R, et al. Among authors: adornato i. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3712-3720. doi: 10.1016/j.bmcl.2018.10.024. Epub 2018 Oct 15. Bioorg Med Chem Lett. 2018. PMID: 30342956
In Search for Multi-Target Ligands as Potential Agents for Diabetes Mellitus and Its Complications-A Structure-Activity Relationship Study on Inhibitors of Aldose Reductase and Protein Tyrosine Phosphatase 1B.
Ottanà R, Paoli P, Cappiello M, Nguyen TN, Adornato I, Del Corso A, Genovese M, Nesi I, Moschini R, Naß A, Wolber G, Maccari R. Ottanà R, et al. Among authors: adornato i. Molecules. 2021 Jan 10;26(2):330. doi: 10.3390/molecules26020330. Molecules. 2021. PMID: 33435264 Free PMC article.
Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B: In silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents.
Ottanà R, Paoli P, Naß A, Lori G, Cardile V, Adornato I, Rotondo A, Graziano ACE, Wolber G, Maccari R. Ottanà R, et al. Among authors: adornato i. Eur J Med Chem. 2017 Feb 15;127:840-858. doi: 10.1016/j.ejmech.2016.10.063. Epub 2016 Nov 1. Eur J Med Chem. 2017. PMID: 27842892