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Showing results for hyoja ha
Search for Hyoji Ha instead (1 results)
Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives.
Oh EJ, Park K, Kim KS, Kim J, Yang JA, Kong JH, Lee MY, Hoffman AS, Hahn SK. Oh EJ, et al. J Control Release. 2010 Jan 4;141(1):2-12. doi: 10.1016/j.jconrel.2009.09.010. Epub 2009 Sep 13. J Control Release. 2010. PMID: 19758573 Review.
According to the real-time bio-imaging of HA derivatives using quantum dots (QDot), HA-QDot conjugates with 35mol% HA modification maintaining enough binding sites for HA receptors were mainly accumulated in the liver, while those with 68mol% HA …
According to the real-time bio-imaging of HA derivatives using quantum dots (QDot), HA-QDot conjugates with 35mol% HA m …
Target-specific gene silencing of layer-by-layer assembled gold-cysteamine/siRNA/PEI/HA nanocomplex.
Lee MY, Park SJ, Park K, Kim KS, Lee H, Hahn SK. Lee MY, et al. ACS Nano. 2011 Aug 23;5(8):6138-47. doi: 10.1021/nn2017793. Epub 2011 Jul 8. ACS Nano. 2011. PMID: 21739990
In this work, a cysteamine modified gold nanoparticles (AuCM)/siRNA/polyethyleneimine (PEI)/hyaluronic acid (HA) complex was successfully developed using a layer-by-layer method for target-specific intracellular delivery of siRNA by HA receptor mediated endocytosis. …
In this work, a cysteamine modified gold nanoparticles (AuCM)/siRNA/polyethyleneimine (PEI)/hyaluronic acid (HA) complex was successf …
Target specific systemic delivery of TGF-beta siRNA/(PEI-SS)-g-HA complex for the treatment of liver cirrhosis.
Park K, Hong SW, Hur W, Lee MY, Yang JA, Kim SW, Yoon SK, Hahn SK. Park K, et al. Biomaterials. 2011 Jul;32(21):4951-8. doi: 10.1016/j.biomaterials.2011.03.044. Epub 2011 Apr 11. Biomaterials. 2011. PMID: 21481451
The confocal microscopic and fluorometric analyses confirmed the effective cellular uptake of siRNA/(PEI-SS)-g-HA complex by HA receptor mediated endocytosis. In vitro gene silencing efficiency was ca. 80% in the presence of 10 vol% serum and ca. 50% in the presence …
The confocal microscopic and fluorometric analyses confirmed the effective cellular uptake of siRNA/(PEI-SS)-g-HA complex by HA …
Transdermal delivery of hyaluronic acid -- human growth hormone conjugate.
Yang JA, Kim ES, Kwon JH, Kim H, Shin JH, Yun SH, Choi KY, Hahn SK. Yang JA, et al. Biomaterials. 2012 Sep;33(25):5947-54. doi: 10.1016/j.biomaterials.2012.05.003. Epub 2012 May 25. Biomaterials. 2012. PMID: 22632765
Hyaluronic acid (HA) is one of the major components of extracellular matrix (ECM). ...HA-hGH conjugate was synthesized by specific coupling reaction between aldehyde modified HA and the N-terminal amine group of hGH. ...
Hyaluronic acid (HA) is one of the major components of extracellular matrix (ECM). ...HA-hGH conjugate was synthesized by spec …
Reducible hyaluronic acid-siRNA conjugate for target specific gene silencing.
Park K, Yang JA, Lee MY, Lee H, Hahn SK. Park K, et al. Bioconjug Chem. 2013 Jul 17;24(7):1201-9. doi: 10.1021/bc4001257. Epub 2013 Jun 17. Bioconjug Chem. 2013. PMID: 23731084
The HA-siRNA/LPEI complex had a mean particle size of ca. 250 nm and a negative or neutral surface charge at physiological condition. The reducible HA-siRNA/LPEI complex showed a higher in vitro gene silencing efficiency than noncleavable HA-siRNA/LPEI comple …
The HA-siRNA/LPEI complex had a mean particle size of ca. 250 nm and a negative or neutral surface charge at physiological condition. …
Injectable hyaluronic acid-tyramine hydrogels for the treatment of rheumatoid arthritis.
Kim KS, Park SJ, Yang JA, Jeon JH, Bhang SH, Kim BS, Hahn SK. Kim KS, et al. Acta Biomater. 2011 Feb;7(2):666-74. doi: 10.1016/j.actbio.2010.09.030. Epub 2010 Sep 29. Acta Biomater. 2011. PMID: 20883838
Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by inflammation of the synovial membrane, leading in turn to articular cartilage destruction. In this work, injectable tyramine modified hyaluronic acid (HA-Tyr) hydrogels were developed for the treatment o …
Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by inflammation of the synovial membrane, leading in turn to articular ca …
Targeted systemic mesenchymal stem cell delivery using hyaluronate - wheat germ agglutinin conjugate.
Kim YS, Kong WH, Kim H, Hahn SK. Kim YS, et al. Biomaterials. 2016 Nov;106:217-27. doi: 10.1016/j.biomaterials.2016.08.027. Epub 2016 Aug 18. Biomaterials. 2016. PMID: 27569867
A variety of receptors for hyaluronate (HA), a natural linear polysaccharide, were found in the body, which have been exploited as target sites for HA-based drug delivery systems. ...WGA was conjugated to HA by coupling reaction between aldehyde-modified H …
A variety of receptors for hyaluronate (HA), a natural linear polysaccharide, were found in the body, which have been exploited as ta …
Hyaluronic acid-tumor necrosis factor-related apoptosis-inducing ligand conjugate for targeted treatment of liver fibrosis.
Yang JA, Kong WH, Sung DK, Kim H, Kim TH, Lee KC, Hahn SK. Yang JA, et al. Acta Biomater. 2015 Jan;12:174-182. doi: 10.1016/j.actbio.2014.10.002. Epub 2014 Oct 13. Acta Biomater. 2015. PMID: 25305513
The HA-TRAIL conjugate was synthesized by a coupling reaction between aldehyde-modified HA and the N-terminal amine group of TRAIL. ...Finally, we could confirm the antifibrotic effect of HA-TRAIL conjugate in an N-nitrosodimethylamine-induced liver fibrosis …
The HA-TRAIL conjugate was synthesized by a coupling reaction between aldehyde-modified HA and the N-terminal amine group of T …
In situ supramolecular assembly and modular modification of hyaluronic acid hydrogels for 3D cellular engineering.
Park KM, Yang JA, Jung H, Yeom J, Park JS, Park KH, Hoffman AS, Hahn SK, Kim K. Park KM, et al. ACS Nano. 2012 Apr 24;6(4):2960-8. doi: 10.1021/nn204123p. Epub 2012 Mar 15. ACS Nano. 2012. PMID: 22404424
A facile in situ supramolecular assembly and modular modification of biocompatible hydrogels were demonstrated using cucurbit[6]uril-conjugated hyaluronic acid (CB[6]-HA), diaminohexane-conjugated HA (DAH-HA), and tags-CB[6] for cellular engineering applicati …
A facile in situ supramolecular assembly and modular modification of biocompatible hydrogels were demonstrated using cucurbit[6]uril-conjuga …
Nanographene oxide-hyaluronic acid conjugate for photothermal ablation therapy of skin cancer.
DJung HS, Kong WH, Sung DK, Lee MY, Beack SE, Keum DH, Kim KS, Yun SH, Hahn SK. DJung HS, et al. ACS Nano. 2014 Jan 28;8(1):260-8. doi: 10.1021/nn405383a. Epub 2014 Jan 2. ACS Nano. 2014. PMID: 24383990
In this work, a nanographene oxide-HA conjugate (NGO-HA) was synthesized for photothermal ablation therapy of melanoma skin cancer using a near-infrared (NIR) laser. ...Taken together, we could confirm the feasibility of transdermal NGO-HA for photothermal ab …
In this work, a nanographene oxide-HA conjugate (NGO-HA) was synthesized for photothermal ablation therapy of melanoma skin ca …
72 results