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Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities.
Ho TLF, Lee MY, Goh HC, Ng GYN, Lee JJH, Kannan S, Lim YT, Zhao T, Lim EKH, Phua CZJ, Lee YF, Lim RYX, Ng PJH, Yuan J, Chan DKH, Lieske B, Chong CS, Lee KC, Lum J, Cheong WK, Yeoh KG, Tan KK, Sobota RM, Verma CS, Lane DP, Tam WL, Venkitaraman AR. Ho TLF, et al. Among authors: goh hc. Nat Commun. 2023 Mar 28;14(1):1726. doi: 10.1038/s41467-023-37223-3. Nat Commun. 2023. PMID: 36977662 Free PMC article.
Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity.
Zheng S, Koh XY, Goh HC, Rahmat SAB, Hwang LA, Lane DP. Zheng S, et al. Among authors: goh hc. Cancer Res. 2017 Aug 15;77(16):4342-4354. doi: 10.1158/0008-5472.CAN-17-0424. Epub 2017 Jun 27. Cancer Res. 2017. PMID: 28655792
Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity.
Wang YH, Ho TLF, Hariharan A, Goh HC, Wong YL, Verkaik NS, Lee MY, Tam WL, van Gent DC, Venkitaraman AR, Sheetz MP, Lane DP. Wang YH, et al. Among authors: goh hc. Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2113233119. doi: 10.1073/pnas.2113233119. Epub 2022 Mar 2. Proc Natl Acad Sci U S A. 2022. PMID: 35235448 Free PMC article.