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Characterization of imidazo[4,5-d]pyridazine nucleosides as modulators of unwinding reaction mediated by West Nile virus nucleoside triphosphatase/helicase: evidence for activity on the level of substrate and/or enzyme.
Borowski P, Lang M, Haag A, Schmitz H, Choe J, Chen HM, Hosmane RS. Borowski P, et al. Among authors: chen hm. Antimicrob Agents Chemother. 2002 May;46(5):1231-9. doi: 10.1128/AAC.46.5.1231-1239.2002. Antimicrob Agents Chemother. 2002. PMID: 11959550 Free PMC article.
Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus.
Zhang N, Chen HM, Koch V, Schmitz H, Liao CL, Bretner M, Bhadti VS, Fattom AI, Naso RB, Hosmane RS, Borowski P. Zhang N, et al. Among authors: chen hm. J Med Chem. 2003 Sep 11;46(19):4149-64. doi: 10.1021/jm030842j. J Med Chem. 2003. PMID: 12954067