Synthesis and biological activity of trans-tiliroside derivatives as potent anti-diabetic agents

Molecules. 2010 Dec 10;15(12):9174-83. doi: 10.3390/molecules15129174.

Abstract

A set of novel trans-tiliroside derivatives were synthesized. The structures of the derivatives were identified by their IR, 1H-NMR, and MS spectra analysis. Their anti-diabetic activities were evaluated on the insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, and trans-tiliroside exhibited significant glucose consumption-enhancing effects in IR-HepG2 cells compared with the positive control (metformin). This research provides useful clues for further design and discovery of anti-diabetic agents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Flavonoids* / chemical synthesis
  • Flavonoids* / chemistry
  • Flavonoids* / pharmacology
  • Glucose / metabolism
  • Hep G2 Cells
  • Humans
  • Hypoglycemic Agents* / chemical synthesis
  • Hypoglycemic Agents* / chemistry
  • Hypoglycemic Agents* / pharmacology
  • Insulin Resistance
  • Magnetic Resonance Spectroscopy
  • Metformin / chemistry
  • Metformin / pharmacology
  • Models, Biological
  • Molecular Structure

Substances

  • Flavonoids
  • Hypoglycemic Agents
  • tiliroside
  • Metformin
  • Glucose