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Trimebutine suppresses Toll-like receptor 2/4/7/8/9 signaling pathways in macrophages.
Ogawa N, Nakajima S, Tamada K, Yokoue N, Tachibana H, Okazawa M, Oyama T, Abe H, Yamazaki H, Yoshimori A, Sato A, Kamiya T, Yokomizo T, Uchiumi F, Abe T, Tanuma SI. Ogawa N, et al. Among authors: yamazaki h. Arch Biochem Biophys. 2021 Oct 30;711:109029. doi: 10.1016/j.abb.2021.109029. Epub 2021 Sep 10. Arch Biochem Biophys. 2021. PMID: 34517011
Structural Basis of Beneficial Design for Effective Nicotinamide Phosphoribosyltransferase Inhibitors.
Tanuma SI, Katsuragi K, Oyama T, Yoshimori A, Shibasaki Y, Asawa Y, Yamazaki H, Makino K, Okazawa M, Ogino Y, Sakamoto Y, Nomura M, Sato A, Abe H, Nakamura H, Takahashi H, Tanuma N, Uchiumi F. Tanuma SI, et al. Among authors: yamazaki h. Molecules. 2020 Aug 10;25(16):3633. doi: 10.3390/molecules25163633. Molecules. 2020. PMID: 32785052 Free PMC article.
A 3-styrylchromone converted from trimebutine 3D pharmacophore possesses dual suppressive effects on RAGE and TLR4 signaling pathways.
Okazawa M, Oyama T, Abe H, Yamazaki H, Yoshimori A, Tsukimoto M, Yoshizawa K, Takao K, Sugita Y, Kamiya T, Uchiumi F, Sakagami H, Abe T, Tanuma SI. Okazawa M, et al. Among authors: yamazaki h. Biochem Biophys Res Commun. 2021 Aug 20;566:1-8. doi: 10.1016/j.bbrc.2021.05.096. Epub 2021 Jun 7. Biochem Biophys Res Commun. 2021. PMID: 34111666
A Dual Anti-Inflammatory and Anti-Proliferative 3-Styrylchromone Derivative Synergistically Enhances the Anti-Cancer Effects of DNA-Damaging Agents on Colon Cancer Cells by Targeting HMGB1-RAGE-ERK1/2 Signaling.
Tanuma SI, Oyama T, Okazawa M, Yamazaki H, Takao K, Sugita Y, Amano S, Abe T, Sakagami H. Tanuma SI, et al. Among authors: yamazaki h. Int J Mol Sci. 2022 Mar 22;23(7):3426. doi: 10.3390/ijms23073426. Int J Mol Sci. 2022. PMID: 35408786 Free PMC article.
Is prolongation of corrected QT interval associated with seizures induced by electroconvulsive therapy reduced by atropine sulfate?
Suzuki Y, Miyajima M, Ohta K, Yoshida N, Omoya R, Fujiwara M, Watanabe T, Okumura M, Yamazaki H, Shintaku M, Murata I, Ozaki S, Sasaki T, Nakamura M, Suwa H, Sasano T, Kawara T, Matsuura M, Matsushima E. Suzuki Y, et al. Among authors: yamazaki h. Pacing Clin Electrophysiol. 2017 Nov;40(11):1246-1253. doi: 10.1111/pace.13188. Epub 2017 Oct 6. Pacing Clin Electrophysiol. 2017. PMID: 28862317
11 results