Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents

Asami Tsukiashi; Kil Sik Min; Hikaru Kitayama; Hiroaki Terasawa; Sosuke Yoshinaga; Mitsuhiro Takeda; Leonard F Lindoy; Shinya Hayami

doi:10.1038/s41598-018-33362-6

Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents

Sci Rep. 2018 Oct 8;8(1):14911. doi: 10.1038/s41598-018-33362-6.

Authors

Asami Tsukiashi¹, Kil Sik Min², Hikaru Kitayama¹, Hiroaki Terasawa³, Sosuke Yoshinaga³, Mitsuhiro Takeda³, Leonard F Lindoy⁴, Shinya Hayami^{5

6}

Affiliations

¹ Department of Chemistry, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, kumamoto, 860-8555, Japan.
² Department of Chemistry Education and Green-Nano Materials Research Center, Kyungpook National University, Daegu, 41566, Republic of Korea.
³ Department of Structural BioImaging, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto, 862-0973, Japan.
⁴ School of Chemistry, The University of Sydney, Sydney, NSW, 2006, Australia.
⁵ Department of Chemistry, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, kumamoto, 860-8555, Japan. hayami@kumamoto-u.ac.jp.
⁶ Institute of Pulsed Power Science (IPPS), Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto, 860-8555, Japan. hayami@kumamoto-u.ac.jp.

Abstract

Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)_3-3×(NH₂trz)_3×](BF₄)₂ (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280-330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent.

Publication types

Research Support, Non-U.S. Gov't