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The direct renin inhibitor aliskiren localizes and persists in rat kidneys.
Feldman DL, Jin L, Xuan H, Persohn E, Zhou W, Schuetz H, Park JK, Muller DN, Luft FC. Feldman DL, et al. Among authors: schuetz h. Am J Physiol Renal Physiol. 2013 Dec 1;305(11):F1593-602. doi: 10.1152/ajprenal.00655.2012. Epub 2013 Aug 7. Am J Physiol Renal Physiol. 2013. PMID: 23926182 Free article.
Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: the role of P-glycoprotein in the disposition of aliskiren.
Vaidyanathan S, Camenisch G, Schuetz H, Reynolds C, Yeh CM, Bizot MN, Dieterich HA, Howard D, Dole WP. Vaidyanathan S, et al. Among authors: schuetz h. J Clin Pharmacol. 2008 Nov;48(11):1323-38. doi: 10.1177/0091270008323258. Epub 2008 Sep 10. J Clin Pharmacol. 2008. PMID: 18784280 Clinical Trial.