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Treadmill training and physiotherapy similarly improve dual task gait performance: a randomized-controlled trial in Parkinson's disease.
Gaßner H, Trutt E, Seifferth S, Friedrich J, Zucker D, Salhani Z, Adler W, Winkler J, Jost WH. Gaßner H, et al. J Neural Transm (Vienna). 2022 Sep;129(9):1189-1200. doi: 10.1007/s00702-022-02514-4. Epub 2022 Jun 13. J Neural Transm (Vienna). 2022. PMID: 35697942 Free PMC article. Clinical Trial.
Both interventions significantly improved gait in patients with mild to moderate PD. However, treadmill walking did not show significant benefits compared to individualized physiotherapy. ...
Both interventions significantly improved gait in patients with mild to moderate PD. However, treadmill walking did not show signific …
A New Era for Mild Strain Cross-Protection.
Pechinger K, Chooi KM, MacDiarmid RM, Harper SJ, Ziebell H. Pechinger K, et al. Viruses. 2019 Jul 23;11(7):670. doi: 10.3390/v11070670. Viruses. 2019. PMID: 31340444 Free PMC article. Review.
Societal and environmental pressures demand high-quality and resilient cropping plants and plant-based foods grown with the use of low or no synthetic chemical inputs. Mild strain cross-protection (MSCP), the pre-immunization of a plant using a mild strain of a viru …
Societal and environmental pressures demand high-quality and resilient cropping plants and plant-based foods grown with the use of low or no …
Monkeypox in Germany.
Hoffmann C, Jessen H, Boesecke C. Hoffmann C, et al. Dtsch Arztebl Int. 2022 Aug 22;119(33-34):551-557. doi: 10.3238/arztebl.m2022.0287. Dtsch Arztebl Int. 2022. PMID: 35912445 Free PMC article.
The most common general symptoms were fever, headache, limb pain, and, often, painfully swollen lymph nodes. Most infections to date have taken a relatively mild course: 5.0% of the patients were hospitalized, and none died. ...
The most common general symptoms were fever, headache, limb pain, and, often, painfully swollen lymph nodes. Most infections to date have ta …
A FinnGen pilot clinical recall study for Alzheimer's disease.
Julkunen V, Schwarz C, Kalapudas J, Hallikainen M, Piironen AK, Mannermaa A, Kujala H, Laitinen T, Kosma VM, Paajanen TI, Kälviäinen R, Hiltunen M, Herukka SK, Kärkkäinen S, Kokkola T, Urjansson M; FinnGen; Perola M, Palotie A, Vuoksimaa E, Runz H. Julkunen V, et al. Sci Rep. 2023 Aug 3;13(1):12641. doi: 10.1038/s41598-023-39835-7. Sci Rep. 2023. PMID: 37537264 Free PMC article.
Population-based biobanks with comprehensive health and genetic data from large numbers of individuals hold promise to facilitate identification of trial participants, particularly when interventions need to start while symptoms are still mild, such as for Alzheimer's dise …
Population-based biobanks with comprehensive health and genetic data from large numbers of individuals hold promise to facilitate identifica …
Movement disorders in MCT8 deficiency/Allan-Herndon-Dudley Syndrome.
Masnada S, Sarret C, Antonello CE, Fadilah A, Krude H, Mura E, Mordekar S, Nicita F, Olivotto S, Orcesi S, Porta F, Remerand G, Siri B, Wilpert NM, Amir-Yazdani P, Bertini E, Schuelke M, Bernard G, Boespflug-Tanguy O, Tonduti D. Masnada S, et al. Mol Genet Metab. 2022 Jan;135(1):109-113. doi: 10.1016/j.ymgme.2021.12.003. Epub 2021 Dec 16. Mol Genet Metab. 2022. PMID: 34969638
CONCLUSION: MDs are frequent clinical features of MCT8 deficiency, possibly related to the important role of thyroid hormones in brain development and functioning of normal dopaminergic circuits of the basal ganglia. Dystonia is common, but usually mild to moderate in seve …
CONCLUSION: MDs are frequent clinical features of MCT8 deficiency, possibly related to the important role of thyroid hormones in brain devel …
Prospects for engineering and improvement of cross-protective virus strains.
Ziebell H, MacDiarmid R. Ziebell H, et al. Curr Opin Virol. 2017 Oct;26:8-14. doi: 10.1016/j.coviro.2017.06.010. Epub 2017 Jul 22. Curr Opin Virol. 2017. PMID: 28743041 Review.
Mild strain cross-protection is currently an important method for the production of high quality plant products; despite challenge from severe virus isolates the initial protecting strain precludes symptom development. ...We propose two additional requirements for effectiv …
Mild strain cross-protection is currently an important method for the production of high quality plant products; despite challenge fr …
NKX2.1-Related Disorders: a novel mutation with mild clinical presentation.
Monti S, Nicoletti A, Cantasano A, Krude H, Cassio A. Monti S, et al. Ital J Pediatr. 2015 Jun 24;41:45. doi: 10.1186/s13052-015-0150-6. Ital J Pediatr. 2015. PMID: 26103969 Free PMC article.
We describe here the case of an infant with a novel mutation of the NKX2.1 gene characterized by mild clinical presentation. Aim of the study was to elucidate the genotype-phenotype correlation in our patient. ...RESULTS: A novel mutation of the NKX2.1 gene has been identi …
We describe here the case of an infant with a novel mutation of the NKX2.1 gene characterized by mild clinical presentation. Aim of t …
Covalently bound humin-lignin hybrids as important novel substructures in organosolv spruce lignins.
Thoresen PP, Lange H, Rova U, Christakopoulos P, Matsakas L. Thoresen PP, et al. Int J Biol Macromol. 2023 Apr 1;233:123471. doi: 10.1016/j.ijbiomac.2023.123471. Epub 2023 Feb 1. Int J Biol Macromol. 2023. PMID: 36736515
Applying advanced NMR, GPC, and thermal analyses, isolated spruce lignins were analysed to correlate organosolv process severity to the structural details for delineating potential valorisations. Very mild conditions were found to not fractionate the biomass, causing a mix …
Applying advanced NMR, GPC, and thermal analyses, isolated spruce lignins were analysed to correlate organosolv process severity to the stru …
Cross-protection: a century of mystery.
Ziebell H, Carr JP. Ziebell H, et al. Adv Virus Res. 2010;76:211-64. doi: 10.1016/S0065-3527(10)76006-1. Epub 2010 Mar 31. Adv Virus Res. 2010. PMID: 20965075
Cross-protection is a phenomenon in which infection of a plant with a mild virus or viroid strain protects it from disease resulting from a subsequent encounter with a severe strain of the same virus or viroid. ...
Cross-protection is a phenomenon in which infection of a plant with a mild virus or viroid strain protects it from disease resulting …
Influence of fibrosis progression on the viscous properties of in vivo liver tissue elucidated by shear wave dispersion in multifrequency MR elastography.
Reiter R, Shahryari M, Tzschätzsch H, Haas M, Bayerl C, Siegmund B, Hamm B, Asbach P, Braun J, Sack I. Reiter R, et al. J Mech Behav Biomed Mater. 2021 Sep;121:104645. doi: 10.1016/j.jmbbm.2021.104645. Epub 2021 Jun 18. J Mech Behav Biomed Mater. 2021. PMID: 34166871

RESULTS: While SWS increased with fibrosis (F0: 1.53 0.11 m/s, F1-F3: 1.71 0.17 m/s, F4: 2.50 0.39 m/s; P < 0.001), phi remained unchanged during mild to severe fibrosis (F0: 0.63 0.05 rad, F1-F3: 0.60 0.05 rad, P = 0.21) but increased in cirrhosis (F4: 0.81 0.16 rad; P

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RESULTS: While SWS increased with fibrosis (F0: 1.53 0.11 m/s, F1-F3: 1.71 0.17 m/s, F4: 2.50 0.39 m/s; P < 0.001), phi remained unchange

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14 results