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The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola.
Cwiklinski K, Donnelly S, Drysdale O, Jewhurst H, Smith D, De Marco Verissimo C, Pritsch IC, O'Neill S, Dalton JP, Robinson MW. Cwiklinski K, et al. Among authors: jewhurst h. Adv Parasitol. 2019;104:113-164. doi: 10.1016/bs.apar.2019.01.001. Epub 2019 Feb 26. Adv Parasitol. 2019. PMID: 31030768 Review.
Autonomous Non Antioxidant Roles for Fasciola hepatica Secreted Thioredoxin-1 and Peroxiredoxin-1.
Dorey A, Cwiklinski K, Rooney J, De Marco Verissimo C, López Corrales J, Jewhurst H, Fazekas B, Calvani NED, Hamon S, Gaughan S, Dalton JP, Lalor R. Dorey A, et al. Among authors: jewhurst h. Front Cell Infect Microbiol. 2021 May 5;11:667272. doi: 10.3389/fcimb.2021.667272. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 34026663 Free PMC article. Review.
Production of a functionally active recombinant SARS-CoV-2 (COVID-19) 3C-like protease and a soluble inactive 3C-like protease-RBD chimeric in a prokaryotic expression system.
De Marco Verissimo C, López Corrales J, Dorey AL, Cwiklinski K, Lalor R, Calvani NED, Jewhurst HL, Flaus A, Doyle S, Dalton JP. De Marco Verissimo C, et al. Among authors: jewhurst hl. Epidemiol Infect. 2022 Jun 20;150:e128. doi: 10.1017/S0950268822001078. Epidemiol Infect. 2022. PMID: 35723031 Free PMC article.
Fasciola hepatica is refractory to complement killing by preventing attachment of mannose binding lectin (MBL) and inhibiting MBL-associated serine proteases (MASPs) with serpins.
De Marco Verissimo C, Jewhurst HL, Dobó J, Gál P, Dalton JP, Cwiklinski K. De Marco Verissimo C, et al. Among authors: jewhurst hl. PLoS Pathog. 2022 Jan 10;18(1):e1010226. doi: 10.1371/journal.ppat.1010226. eCollection 2022 Jan. PLoS Pathog. 2022. PMID: 35007288 Free PMC article.
Two Distinct Superoxidase Dismutases (SOD) Secreted by the Helminth Parasite Fasciola hepatica Play Roles in Defence against Metabolic and Host Immune Cell-Derived Reactive Oxygen Species (ROS) during Growth and Development.
Calvani NED, De Marco Verissimo C, Jewhurst HL, Cwiklinski K, Flaus A, Dalton JP. Calvani NED, et al. Among authors: jewhurst hl. Antioxidants (Basel). 2022 Sep 30;11(10):1968. doi: 10.3390/antiox11101968. Antioxidants (Basel). 2022. PMID: 36290692 Free PMC article.
Fasciola hepatica antioxidant and protease-inhibitor cocktail recombinant vaccines administered five times elicit potent and sustained immune responses in sheep but do not confer protection.
Cwiklinski K, McEvoy A, López Corrales J, Jewhurst H, Calvani NED, De Marco Verissimo C, Dorey AL, Keane OM, Dalton JP, Lalor R. Cwiklinski K, et al. Among authors: jewhurst h. Vet Parasitol. 2023 Oct 8;323:110049. doi: 10.1016/j.vetpar.2023.110049. Online ahead of print. Vet Parasitol. 2023. PMID: 37826973 Free article.
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