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Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex.
Prakash R, Sandoval T, Morati F, Zagelbaum JA, Lim PX, White T, Taylor B, Wang R, Desclos ECB, Sullivan MR, Rein HL, Bernstein KA, Krawczyk PM, Gautier J, Modesti M, Vanoli F, Jasin M. Prakash R, et al. Among authors: rein hl. Nat Commun. 2021 Jul 12;12(1):4255. doi: 10.1038/s41467-021-24205-6. Nat Commun. 2021. PMID: 34253720 Free PMC article.
Homologous recombination-deficient mutation cluster in tumor suppressor RAD51C identified by comprehensive analysis of cancer variants.
Prakash R, Rawal Y, Sullivan MR, Grundy MK, Bret H, Mihalevic MJ, Rein HL, Baird JM, Darrah K, Zhang F, Wang R, Traina TA, Radke MR, Kaufmann SH, Swisher EM, Guérois R, Modesti M, Sung P, Jasin M, Bernstein KA. Prakash R, et al. Among authors: rein hl. Proc Natl Acad Sci U S A. 2022 Sep 20;119(38):e2202727119. doi: 10.1073/pnas.2202727119. Epub 2022 Sep 13. Proc Natl Acad Sci U S A. 2022. PMID: 36099300 Free PMC article.
The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA.
Hengel SR, Oppenheimer K, Smith C, Schaich MA, Rein HL, Martino J, Darrah K, Ezekwenna O, Burton K, Van Houten B, Spies M, Bernstein KA. Hengel SR, et al. Among authors: rein hl. bioRxiv [Preprint]. 2024 Feb 15:2024.02.14.580393. doi: 10.1101/2024.02.14.580393. bioRxiv. 2024. PMID: 38405734 Free PMC article. Preprint.
Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase.
Jiang Z, Lai Y, Beaver JM, Tsegay PS, Zhao ML, Horton JK, Zamora M, Rein HL, Miralles F, Shaver M, Hutcheson JD, Agoulnik I, Wilson SH, Liu Y. Jiang Z, et al. Among authors: rein hl. Cells. 2020 Jan 16;9(1):225. doi: 10.3390/cells9010225. Cells. 2020. PMID: 31963223 Free PMC article.