Evaluating resistance to acetyl salicylic acid using platelet function test in patients with ischemic stroke at Cipto Mangunkusumo Hospital

Acta Med Indones. 2015 Apr;47(2):88-94.

Abstract

Aim: to identify the prevalence of laboratoric ASA resistance using platelet function tests in patients with ischemic stroke at Cipto Mangunkusumo Hospital and its associated factors.

Methods: this study was a cross-sectional study involving 50 patients with ischemic stroke who only received ASA treatment. Evaluation of resistance to ASA was performed using Verifynow® platelet function test. ASA resistance was defined as ASA reaction unit (ARU) 550.

Results: there were 7 patients with ASA resistance. The mean age of subjects in ASA resistance group was 51.3±9.2 years; while in ASA responsive group was 57.8±9.7 years. In ASA resistance group, there were 85.7% male patients, 57.1% active smoker and 100% subjects with hypertension.

Conclusion: the prevalence of laboratoric ASA resistance in patients with ischemic stroke evaluated using platelet function test at Cipto Mangunkusumo Hospital is 14%. The prevalence is more likely to occur in male patients who were active smoker, at younger age and with comorbidity of hypertension.

MeSH terms

  • Aged
  • Aspirin / therapeutic use*
  • Comorbidity
  • Cross-Sectional Studies
  • Drug Resistance*
  • Female
  • Humans
  • Hypertension / complications*
  • Indonesia
  • Male
  • Middle Aged
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Platelet Function Tests
  • Sex Factors
  • Stroke / drug therapy*

Substances

  • Platelet Aggregation Inhibitors
  • Aspirin