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Closed-system manufacturing of CD19 and dual-targeted CD20/19 chimeric antigen receptor T cells using the CliniMACS Prodigy device at an academic medical center.
Zhu F, Shah N, Xu H, Schneider D, Orentas R, Dropulic B, Hari P, Keever-Taylor CA. Zhu F, et al. Cytotherapy. 2018 Mar;20(3):394-406. doi: 10.1016/j.jcyt.2017.09.005. Epub 2017 Dec 26. Cytotherapy. 2018. PMID: 29287970
An average 30-fold expansion of 10(8) CD4/CD8-enriched cells resulted in sufficient transduced T cells for clinical use. CAR-T cells were 82-100% CD3(+) with a mix of CD4(+) and CD8(+) cells that primarily expressed an effector-memory or central-memory phenot …
An average 30-fold expansion of 10(8) CD4/CD8-enriched cells resulted in sufficient transduced T cells for clinical use. CAR-T …
Statin therapy in critical illness: an international survey of intensive care physicians' opinions, attitudes and practice.
Shankar-Hari M, Kruger PS, Di Gangi S, Scales DC, Perkins GD, McAuley DF, Terblanche M. Shankar-Hari M, et al. BMC Clin Pharmacol. 2012 Jun 28;12:13. doi: 10.1186/1472-6904-12-13. BMC Clin Pharmacol. 2012. PMID: 22742644 Free PMC article.
RESULTS: Of 239 respondents (62 from ANZ and 177 from UK) 58% worked in teaching hospitals; most (78.2%) practised in 'closed' units with a mixed medical and surgical case mix (71.0%). The most frequently prescribed statins were simvastatin (77.6%) in the UK and atorvastat …
RESULTS: Of 239 respondents (62 from ANZ and 177 from UK) 58% worked in teaching hospitals; most (78.2%) practised in 'closed' units with a …
Intravenous immunoglobulin for severe sepsis and septic shock: clinical effectiveness, cost-effectiveness and value of a further randomised controlled trial.
Soares MO, Welton NJ, Harrison DA, Peura P, Shankar-Hari M, Harvey SE, Madan J, Ades AE, Rowan KM, Palmer SJ. Soares MO, et al. Crit Care. 2014 Dec 1;18(6):649. doi: 10.1186/s13054-014-0649-z. Crit Care. 2014. PMID: 25434816 Free PMC article.
Further primary data analyses were also undertaken using the Intensive Care National Audit & Research Centre Case Mix Programme Database, and a Scottish Intensive Care Society research study. ...
Further primary data analyses were also undertaken using the Intensive Care National Audit & Research Centre Case Mix Programme D …