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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1997 1
1998 2
1999 1
2000 2
2003 1
2004 1
2010 1
2013 1
2014 1
2015 2
2016 2
2018 1
2021 1
2022 1
2024 0

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17 results

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Page 1
Forecasting stroke-like episodes and outcomes in mitochondrial disease.
Ng YS, Lax NZ, Blain AP, Erskine D, Baker MR, Polvikoski T, Thomas RH, Morris CM, Lai M, Whittaker RG, Gebbels A, Winder A, Hall J, Feeney C, Farrugia ME, Hirst C, Roberts M, Lawthom C, Chrysostomou A, Murphy K, Baird T, Maddison P, Duncan C, Poulton J, Nesbitt V, Hanna MG, Pitceathly RDS, Taylor RW, Blakely EL, Schaefer AM, Turnbull DM, McFarland R, Gorman GS. Ng YS, et al. Brain. 2022 Apr 18;145(2):542-554. doi: 10.1093/brain/awab353. Brain. 2022. PMID: 34927673 Free PMC article.
The primary outcome was to interrogate the clinico-radiopathological correlates and prognostic indicators of stroke-like episode in patients with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome (MELAS). The secondary objective was …
The primary outcome was to interrogate the clinico-radiopathological correlates and prognostic indicators of stroke-like episode in patients …
Mitochondrial Strokes: Diagnostic Challenges and Chameleons.
Pizzamiglio C, Bugiardini E, Macken WL, Woodward CE, Hanna MG, Pitceathly RDS. Pizzamiglio C, et al. Genes (Basel). 2021 Oct 19;12(10):1643. doi: 10.3390/genes12101643. Genes (Basel). 2021. PMID: 34681037 Free PMC article.
Mitochondrial stroke-like episodes (SLEs) are a hallmark of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). They should be suspected in anyone with an acute/subacute onset of focal neurological symptoms at any age and are usually driven …
Mitochondrial stroke-like episodes (SLEs) are a hallmark of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (M …
Mitochondrial disease: mutations and mechanisms.
McKenzie M, Liolitsa D, Hanna MG. McKenzie M, et al. Neurochem Res. 2004 Mar;29(3):589-600. doi: 10.1023/b:nere.0000014829.42364.dd. Neurochem Res. 2004. PMID: 15038606 Review.
Sar1 GTPase Activity Is Regulated by Membrane Curvature.
Hanna MG 4th, Mela I, Wang L, Henderson RM, Chapman ER, Edwardson JM, Audhya A. Hanna MG 4th, et al. J Biol Chem. 2016 Jan 15;291(3):1014-27. doi: 10.1074/jbc.M115.672287. Epub 2015 Nov 6. J Biol Chem. 2016. PMID: 26546679 Free PMC article.
MT-ND5 Mutation Exhibits Highly Variable Neurological Manifestations at Low Mutant Load.
Ng YS, Lax NZ, Maddison P, Alston CL, Blakely EL, Hepplewhite PD, Riordan G, Meldau S, Chinnery PF, Pierre G, Chronopoulou E, Du A, Hughes I, Morris AA, Kamakari S, Chrousos G, Rodenburg RJ, Saris CGJ, Feeney C, Hardy SA, Sakakibara T, Sudo A, Okazaki Y, Murayama K, Mundy H, Hanna MG, Ohtake A, Schaefer AM, Champion MP, Turnbull DM, Taylor RW, Pitceathly RDS, McFarland R, Gorman GS. Ng YS, et al. EBioMedicine. 2018 Apr;30:86-93. doi: 10.1016/j.ebiom.2018.02.010. Epub 2018 Feb 24. EBioMedicine. 2018. PMID: 29506874 Free PMC article.
Mutations in the m.13094T>C MT-ND5 gene have been previously described in three cases of Leigh Syndrome (LS). In this retrospective, international cohort study we identified 20 clinically affected individuals (13 families) and four asymptomatic carriers. ...Neuropatholo …
Mutations in the m.13094T>C MT-ND5 gene have been previously described in three cases of Leigh Syndrome (LS). In this retrospectiv …
A Clinical, Neuropathological and Genetic Study of Homozygous A467T POLG-Related Mitochondrial Disease.
Rajakulendran S, Pitceathly RD, Taanman JW, Costello H, Sweeney MG, Woodward CE, Jaunmuktane Z, Holton JL, Jacques TS, Harding BN, Fratter C, Hanna MG, Rahman S. Rajakulendran S, et al. PLoS One. 2016 Jan 6;11(1):e0145500. doi: 10.1371/journal.pone.0145500. eCollection 2016. PLoS One. 2016. PMID: 26735972 Free PMC article.
One patient presented with the severe and lethal Alpers-Huttenlocher syndrome, which was confirmed on neuropathology, and was found to have a depletion of mitochondrial DNA (mtDNA). Of the remaining three patients, one presented with mitochondrial encephalomyopathy, lactic …
One patient presented with the severe and lethal Alpers-Huttenlocher syndrome, which was confirmed on neuropathology, and was found t …
The urinary proteome and metabonome differ from normal in adults with mitochondrial disease.
Hall AM, Vilasi A, Garcia-Perez I, Lapsley M, Alston CL, Pitceathly RD, McFarland R, Schaefer AM, Turnbull DM, Beaumont NJ, Hsuan JJ, Cutillas PR, Lindon JC, Holmes E, Unwin RJ, Taylor RW, Gorman GS, Rahman S, Hanna MG. Hall AM, et al. Kidney Int. 2015 Mar;87(3):610-22. doi: 10.1038/ki.2014.297. Epub 2014 Sep 10. Kidney Int. 2015. PMID: 25207879 Free article.
Seventy-five patients had the m.3243A>G mutation and the most frequent phenotypes within the entire cohort were 14 with MELAS, 33 with MIDD, and 17 with MERRF. Urinary RBP was increased in 29 of 75 of m.3243A>G patients, whereas albumin was increased in 23 of the 75. …
Seventy-five patients had the m.3243A>G mutation and the most frequent phenotypes within the entire cohort were 14 with MELAS, 33 …
Increased risk of stroke in patients with the A12308G polymorphism in mitochondria.
Pulkes T, Sweeney MG, Hanna MG. Pulkes T, et al. Lancet. 2000 Dec 16;356(9247):2068-9. doi: 10.1016/s0140-6736(00)03408-5. Lancet. 2000. PMID: 11145497
Factors which increase the risk of stroke in patients with the A3243G (mitochondrial encephalomyopathy, lactic acidosis, and stroke [MELAS]) mutation in human mitochondrial DNA are unclear. Previous work on lung-cancer cells with an A3243G mutation showed that a mutation i …
Factors which increase the risk of stroke in patients with the A3243G (mitochondrial encephalomyopathy, lactic acidosis, and stroke [MELA …
Complex partial status epilepticus in late-onset MELAS.
Leff AP, McNabb AW, Hanna MG, Clarke CR, Larner AJ. Leff AP, et al. Epilepsia. 1998 Apr;39(4):438-41. doi: 10.1111/j.1528-1157.1998.tb01397.x. Epilepsia. 1998. PMID: 9578035 Free article.
The patient was subsequently shown to have a mitochondrial disorder of the MELAS type, a hitherto unreported association. The case illustrates that CPSE should be added to the list of possible causes of acute neurological deterioration in MELAS patients....
The patient was subsequently shown to have a mitochondrial disorder of the MELAS type, a hitherto unreported association. The case il …
17 results