Biological evaluation of 2'-[18F]fluoroflumazenil ([18F]FFMZ), a potential GABA receptor ligand for PET.
Mitterhauser M, Wadsak W, Wabnegger L, Mien LK, Tögel S, Langer O, Sieghart W, Viernstein H, Kletter K, Dudczak R.
Mitterhauser M, et al.
Nucl Med Biol. 2004 Feb;31(2):291-5. doi: 10.1016/j.nucmedbio.2003.09.003.
Nucl Med Biol. 2004.
PMID: 15013496
Brain uptake was high and followed the order cortex>thalamus>cerebellum>rest brain. Fluoroflumazenil displaced [(3)H]flumazenil binding from membrane GABA(A) receptors with an IC(50)value (3.5 nM) comparable to that of Flumazenil (2.8 nM). ...
Brain uptake was high and followed the order cortex>thalamus>cerebellum>rest brain. Fluoroflumazenil displaced [(3)H]flumaze …