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Remarkable substrate-specificity of CYP6AB3 in Depressaria pastinacella, a highly specialized caterpillar.
Insect Mol Biol. 2006 Apr;15(2):169-79. doi: 10.1111/j.1365-2583.2006.00623.x.
Insect Mol Biol. 2006.
PMID: 16640727
Only imperatorin and bergapten bind in close proximity to the catalytic haem and only imperatorin is metabolized (V(max) and K(m) of 2.412 pmol/min per pmol P450 and 94.28 microm, respectively). ...
Only imperatorin and bergapten bind in close proximity to the catalytic haem and only imperatorin is metabolized (V(max) and K(m) of …
Allelic variation in the Depressaria pastinacella CYP6AB3 protein enhances metabolism of plant allelochemicals by altering a proximal surface residue and potential interactions with cytochrome P450 reductase.
Mao W, Rupasinghe SG, Zangerl AR, Berenbaum MR, Schuler MA.
Mao W, et al.
J Biol Chem. 2007 Apr 6;282(14):10544-52. doi: 10.1074/jbc.M607946200. Epub 2007 Jan 23.
J Biol Chem. 2007.
PMID: 17244619
Free article.
Cloning and heterologous expression of CYP6AB3v2, an allelic variant identified in D. pastinacella, reveals that it metabolizes imperatorin at a rate (V(max) of 10.02 pmol/min/pmol of cytochrome P450 monooxygenase (P450)) significantly higher than CYP6AB3v1 (V(max) …
Cloning and heterologous expression of CYP6AB3v2, an allelic variant identified in D. pastinacella, reveals that it metabolizes imperatorin …
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