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Page 1
Metabolomics analysis and biological investigation of three Malvaceae plants.
Abdelhafez OH, Othman EM, Fahim JR, Desoukey SY, Pimentel-Elardo SM, Nodwell JR, Schirmeister T, Tawfike A, Abdelmohsen UR. Abdelhafez OH, et al. Phytochem Anal. 2020 Mar;31(2):204-214. doi: 10.1002/pca.2883. Epub 2019 Aug 7. Phytochem Anal. 2020. PMID: 31390115
OBJECTIVE: To use the non-targeted metabolomics approach to investigate the chemical profiles of three Malvaceae plants, namely Hibiscus mutabilis L. (Changing rose), H. schizopetalus (Dyer) Hook.f. (Coral Hibiscus), and Malvaviscus arboreus Cav. ...Comparing the distribut …
OBJECTIVE: To use the non-targeted metabolomics approach to investigate the chemical profiles of three Malvaceae plants, namely Hibiscus mut …
A Radiomics Model Based on Synthetic MRI Acquisition for Predicting Neoadjuvant Systemic Treatment Response in Triple-Negative Breast Cancer.
Hwang KP, Elshafeey NA, Kotrotsou A, Chen H, Son JB, Boge M, Mohamed RM, Abdelhafez AH, Adrada BE, Panthi B, Sun J, Musall BC, Zhang S, Candelaria RP, White JB, Ravenberg EE, Tripathy D, Yam C, Litton JK, Huo L, Thompson AM, Wei P, Yang WT, Pagel MD, Ma J, Rauch GM. Hwang KP, et al. Radiol Imaging Cancer. 2023 Jul;5(4):e230009. doi: 10.1148/rycan.230009. Radiol Imaging Cancer. 2023. PMID: 37505106 Free PMC article.
Functional Tumor Volume by Fast Dynamic Contrast-Enhanced MRI for Predicting Neoadjuvant Systemic Therapy Response in Triple-Negative Breast Cancer.
Musall BC, Abdelhafez AH, Adrada BE, Candelaria RP, Mohamed RMM, Boge M, Le-Petross H, Arribas E, Lane DL, Spak DA, Leung JWT, Hwang KP, Son JB, Elshafeey NA, Mahmoud HS, Wei P, Sun J, Zhang S, White JB, Ravenberg EE, Litton JK, Damodaran S, Thompson AM, Moulder SL, Yang WT, Pagel MD, Rauch GM, Ma J. Musall BC, et al. J Magn Reson Imaging. 2021 Jul;54(1):251-260. doi: 10.1002/jmri.27557. Epub 2021 Feb 15. J Magn Reson Imaging. 2021. PMID: 33586845
DCE subtraction images were analyzed in consensus by two breast radiologists with 5 (A.H.A.) and 2 (H.S.M.) years of experience. Tumor volumes (TV) were measured on early and late subtractions. ...
DCE subtraction images were analyzed in consensus by two breast radiologists with 5 (A.H.A.) and 2 (H.S.M.) years of ex …
VEGFR-2 inhibiting effect and molecular modeling of newly synthesized coumarin derivatives as anti-breast cancer agents.
Ahmed EY, Abdel Latif NA, El-Mansy MF, Elserwy WS, Abdelhafez OM. Ahmed EY, et al. Bioorg Med Chem. 2020 Mar 1;28(5):115328. doi: 10.1016/j.bmc.2020.115328. Epub 2020 Jan 21. Bioorg Med Chem. 2020. PMID: 31992477
The in vitro cytotoxic studies revealed that most of the synthesized compounds possessed very promising cytotoxicity against MCF-7, particularly; compounds 4a (IC(50) = 1.24 M) and 3d (IC(50) = 1.65 M) exhibited exceptional activities superior to the positive contro …
The in vitro cytotoxic studies revealed that most of the synthesized compounds possessed very promising cytotoxicity against MCF-7, particul …
Novel quinoline/thiazinan-4-one hybrids; design, synthesis, and molecular docking studies as potential anti-bacterial candidates against MRSA.
Mohamed AH, Mostafa SM, Aly AA, Hassan AA, Osman EM, Nayl AA, Brown AB, Abdelhafez EMN. Mohamed AH, et al. RSC Adv. 2023 May 12;13(21):14631-14640. doi: 10.1039/d3ra01721d. eCollection 2023 May 9. RSC Adv. 2023. PMID: 37188251 Free PMC article.
The structure of the synthesized compounds was characterized by spectral data and elemental analysis, IR, MS, (1)H and (13)C NMR spectroscopy which showed two doublet signals for CH-5 and CH-6 and four sharp singlets for the protons of thiazinane NH, CH[double bond, length …
The structure of the synthesized compounds was characterized by spectral data and elemental analysis, IR, MS, (1)H and (13)C NMR spec …
Systematic Evaluation of Clinical, Nutritional, and Fecal Microbial Factors for Their Association With Colorectal Polyps.
Schult D, Maurer HC, Frolova M, Ringelhan M, Mayr U, Ulrich J, Heilmaier M, Rasch S, Lahmer T, Reitmeier S, Hennig C, Gassner C, Thur N, Will T, Janssen KP, Steiger K, Jesinghaus M, Neuhaus K, Quante M, Haller D, Abdelhafez M, Schmid RM, Middelhoff M. Schult D, et al. Clin Transl Gastroenterol. 2024 Feb 1;15(2):e00660. doi: 10.14309/ctg.0000000000000660. Clin Transl Gastroenterol. 2024. PMID: 38088370 Free PMC article.
Consuming Sucrose- or HFCS-sweetened Beverages Increases Hepatic Lipid and Decreases Insulin Sensitivity in Adults.
Sigala DM, Hieronimus B, Medici V, Lee V, Nunez MV, Bremer AA, Cox CL, Price CA, Benyam Y, Chaudhari AJ, Abdelhafez Y, McGahan JP, Goran MI, Sirlin CB, Pacini G, Tura A, Keim NL, Havel PJ, Stanhope KL. Sigala DM, et al. J Clin Endocrinol Metab. 2021 Oct 21;106(11):3248-3264. doi: 10.1210/clinem/dgab508. J Clin Endocrinol Metab. 2021. PMID: 34265055 Free PMC article.

Main outcome measures were %hepatic lipid, Matsuda insulin sensitivity index (ISI), and Predicted M ISI. RESULTS: Sucrose-SB increased %hepatic lipid (absolute change: 0.6 0.2%) compared with aspartame-SB (-0.2 0.2%, P < 0.05) and compared with baseline (P < 0.001).

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Main outcome measures were %hepatic lipid, Matsuda insulin sensitivity index (ISI), and Predicted M ISI. RESULTS: Sucrose-SB increase …
Gene therapy encoding cell cycle factors to treat chronic ischemic heart failure in rats.
Abouleisa RRE, Tang XL, Ou Q, Salama AM, Woolard A, Hammouri D, Abdelhafez H, Cayton S, Abdulwali SK, Arai M, Sithu ID, Conklin DJ, Bolli R, Mohamed TMA. Abouleisa RRE, et al. Cardiovasc Res. 2024 Mar 13;120(2):152-163. doi: 10.1093/cvr/cvae002. Cardiovasc Res. 2024. PMID: 38175760
Here, we aim to test the long-term efficacy of TNNT2-4Fpolycistronic-NIL in a rat model of chronic IHF, a setting that differs pathophysiologically from subacute IHF and has greater clinical relevance. METHODS AND RESULTS: Rats were subjected to a 2-h coronary occlusion fo …
Here, we aim to test the long-term efficacy of TNNT2-4Fpolycistronic-NIL in a rat model of chronic IHF, a setting that differs pathophysiolo …
16 results