Imaging atherosclerotic plaques by targeting Galectin-3 and activated macrophages using (89Zr)-DFO- Galectin3-F(ab')2 mAb.
Varasteh Z, De Rose F, Mohanta S, Li Y, Zhang X, Miritsch B, Scafetta G, Yin C, Sager HB, Glasl S, Gorpas D, Habenicht AJR, Ntziachristos V, Weber WA, Bartolazzi A, Schwaiger M, D'Alessandria C.
Varasteh Z, et al.
Theranostics. 2021 Jan 1;11(4):1864-1876. doi: 10.7150/thno.50247. eCollection 2021.
Theranostics. 2021.
PMID: 33408786
Free PMC article.
To visualize plaques in vivo, ApoE-KO mice were injected i.v. with (89)Zr-DFO-Gal3-F(ab')(2) mAb and imaged via PET/CT 48 h post injection. Whole length aortas harvested from euthanized mice were processed for Sudan-IV staining, autoradiography, and immunostaining for Gal3 …
To visualize plaques in vivo, ApoE-KO mice were injected i.v. with (89)Zr-DFO-Gal3-F(ab')(2) mAb and imaged via PET/CT 48 h post inje …