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High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3.
Gandhi AK, Kim WM, Sun ZJ, Huang YH, Bonsor DA, Sundberg EJ, Kondo Y, Wagner G, Kuchroo VK, Petsko G, Blumberg RS. Gandhi AK, et al. Sci Rep. 2018 Nov 30;8(1):17512. doi: 10.1038/s41598-018-35754-0. Sci Rep. 2018. PMID: 30504845 Free PMC article.
Significant conformational differences were observed in the B-C, C'-C" and C'-D loops of hTIM-3 compared to mouse (m)TIM-3, hTIM-1 and hTIM-4. Further, the conformation of the C-C' loop of hTIM-3 was notably different from hTIM-4. Consist …
Significant conformational differences were observed in the B-C, C'-C" and C'-D loops of hTIM-3 compared to mous …
Characterization of the translocation-competent complex between the Helicobacter pylori oncogenic protein CagA and the accessory protein CagF.
Bonsor DA, Weiss E, Iosub-Amir A, Reingewertz TH, Chen TW, Haas R, Friedler A, Fischer W, Sundberg EJ. Bonsor DA, et al. J Biol Chem. 2013 Nov 15;288(46):32897-909. doi: 10.1074/jbc.M113.507657. Epub 2013 Sep 26. J Biol Chem. 2013. PMID: 24072713 Free PMC article.
Translocation is dependent on the presence of secretion signals found in both the N- and C-terminal domains of CagA and an interaction with the accessory protein CagF. ...However, it had no apparent effect on CagA translocation. Deletion of the C-terminal helix of C …
Translocation is dependent on the presence of secretion signals found in both the N- and C-terminal domains of CagA and an interactio …
The T cell receptor beta-chain second complementarity determining region loop (CDR2beta governs T cell activation and Vbeta specificity by bacterial superantigens.
Nur-ur Rahman AK, Bonsor DA, Herfst CA, Pollard F, Peirce M, Wyatt AW, Kasper KJ, Madrenas J, Sundberg EJ, McCormick JK. Nur-ur Rahman AK, et al. J Biol Chem. 2011 Feb 11;286(6):4871-81. doi: 10.1074/jbc.M110.189068. Epub 2010 Dec 2. J Biol Chem. 2011. PMID: 21127057 Free PMC article.
Herein we report the crystal structure of human Vbeta2.1 (hVbeta2.1) in complex with the toxic shock syndrome toxin-1 (TSST-1) SAg, and mutagenesis of hVbeta2.1 indicates that the non-canonical length of CDR2beta is a critical determinant for recognition by TSST-1 as well as the …
Herein we report the crystal structure of human Vbeta2.1 (hVbeta2.1) in complex with the toxic shock syndrome toxin-1 (TSST-1) SAg, and muta …