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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1966 2
1971 1
1973 1
1975 7
1976 12
1977 17
1978 14
1979 13
1980 12
1981 11
1982 17
1983 20
1984 22
1985 19
1986 29
1987 35
1988 34
1989 45
1990 42
1991 58
1992 74
1993 81
1994 73
1995 86
1996 85
1997 76
1998 81
1999 81
2000 108
2001 85
2002 110
2003 117
2004 143
2005 138
2006 135
2007 140
2008 145
2009 167
2010 158
2011 183
2012 157
2013 165
2014 203
2015 184
2016 199
2017 163
2018 212
2019 232
2020 222
2021 263
2022 261
2023 230
2024 51

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4,708 results

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Page 1
Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editing.
McAuley GE, Yiu G, Chang PC, Newby GA, Campo-Fernandez B, Fitz-Gibbon ST, Wu X, Kang SL, Garibay A, Butler J, Christian V, Wong RL, Everette KA, Azzun A, Gelfer H, Seet CS, Narendran A, Murguia-Favela L, Romero Z, Wright N, Liu DR, Crooks GM, Kohn DB. McAuley GE, et al. Cell. 2023 Mar 30;186(7):1398-1416.e23. doi: 10.1016/j.cell.2023.02.027. Epub 2023 Mar 20. Cell. 2023. PMID: 36944331 Free PMC article.
CD3delta SCID is a devastating inborn error of immunity caused by mutations in CD3D, encoding the invariant CD3delta chain of the CD3/TCR complex necessary for normal thymopoiesis. We demonstrate an adenine base editing (ABE) strategy to restore CD3delta in autologous hema …
CD3delta SCID is a devastating inborn error of immunity caused by mutations in CD3D, encoding the invariant CD3delta chain of the CD3/TCR co …
Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy.
Nishiyama T, Zhang Y, Cui M, Li H, Sanchez-Ortiz E, McAnally JR, Tan W, Kim J, Chen K, Xu L, Bassel-Duby R, Olson EN. Nishiyama T, et al. Sci Transl Med. 2022 Nov 23;14(672):eade1633. doi: 10.1126/scitranslmed.ade1633. Epub 2022 Nov 23. Sci Transl Med. 2022. PMID: 36417486 Free PMC article.
Using ABE to correct RBM20(R634Q) human iPSCs, we achieved 92% efficiency of A-to-G editing, which normalized alternative splicing of cardiac genes, restored nuclear localization of RBM20, and eliminated RNP granule formation. ...As seen by RNA sequencing analysis, ABE …
Using ABE to correct RBM20(R634Q) human iPSCs, we achieved 92% efficiency of A-to-G editing, which normalized alternative splicing of …
Detection of protein palmitoylation in cultured hippocampal neurons by immunoprecipitation and acyl-biotin exchange (ABE).
Brigidi GS, Bamji SX. Brigidi GS, et al. J Vis Exp. 2013 Feb 18;(72):50031. doi: 10.3791/50031. J Vis Exp. 2013. PMID: 23438969 Free PMC article.
Purification of the thiol-biotinylated proteins following the ABE steps has differed, depending on the overall goal of the experiment. Here, we describe a method to purify a palmitoylated protein of interest in primary hippocampal neurons by an initial immunoprecipitation …
Purification of the thiol-biotinylated proteins following the ABE steps has differed, depending on the overall goal of the experiment …
RNA imaging by chemical probes.
Tomoike F, Abe H. Tomoike F, et al. Adv Drug Deliv Rev. 2019 Jul;147:44-58. doi: 10.1016/j.addr.2019.08.001. Epub 2019 Aug 6. Adv Drug Deliv Rev. 2019. PMID: 31398387 Review.
Pharmacological Enhancement of Stroke Rehabilitation.
Abe H, Jitsuki S, Takahashi T. Abe H, et al. Stroke. 2019 Nov;50(11):3323-3329. doi: 10.1161/STROKEAHA.119.023720. Epub 2019 Oct 9. Stroke. 2019. PMID: 31594462 Review. No abstract available.
Rescue of hearing by adenine base editing in a humanized mouse model of Usher syndrome type 1F.
Peters CW, Hanlon KS, Ivanchenko MV, Zinn E, Linarte EF, Li Y, Levy JM, Liu DR, Kleinstiver BP, Indzhykulian AA, Corey DP. Peters CW, et al. Mol Ther. 2023 Aug 2;31(8):2439-2453. doi: 10.1016/j.ymthe.2023.06.007. Epub 2023 Jun 12. Mol Ther. 2023. PMID: 37312453
We packaged a split-intein ABE into dual adeno-associated virus (AAV) vectors and delivered them into cochleas of neonatal USH1F mice. ...This study demonstrates the ability of an ABE to correct the PCDH15 R245X mutation in the cochlea and restore hearing....
We packaged a split-intein ABE into dual adeno-associated virus (AAV) vectors and delivered them into cochleas of neonatal USH1F mice …
Single-nucleotide editing: From principle, optimization to application.
Tang J, Lee T, Sun T. Tang J, et al. Hum Mutat. 2019 Dec;40(12):2171-2183. doi: 10.1002/humu.23819. Epub 2019 Sep 15. Hum Mutat. 2019. PMID: 31131955 Free PMC article. Review.
Moreover, we highlight their applications in mouse and human cells and discuss the challenges and prospects of base editors. The ABE- and CBE systems have been used in gene silencing, pathogenic gene correction, and functional genetic screening. ...
Moreover, we highlight their applications in mouse and human cells and discuss the challenges and prospects of base editors. The ABE- …
Neoirietriol.
Takahashi H, Takahashi Y, Suzuki M, Abe T, Masuda M. Takahashi H, et al. Acta Crystallogr Sect E Struct Rep Online. 2010 Jun 26;66(Pt 7):o1795. doi: 10.1107/S1600536810022336. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21588005 Free PMC article.
The title compound {systematic name: (1R,4S,4aS,7R,8aR)-4-bromo-7-[(1S,3R)-3-bromo-1,2,2-trimethyl-cyclo-pent-yl]-1,4a-dimethyl-deca-hydro-naphthalene-1,7,8a-triol}, C(20)H(34)Br(2)O(3), is a neoirieane-type bromo-diterpenoid isolated from Laurencia yonaguniensis Masuda et …
The title compound {systematic name: (1R,4S,4aS,7R,8aR)-4-bromo-7-[(1S,3R)-3-bromo-1,2,2-trimethyl-cyclo-pent-yl]-1,4a-dimethyl-deca-hydro-n …
Isolation of H(+),K(+)-ATPase-enriched Membrane Fraction from Pig Stomachs.
Abe K, Olesen C. Abe K, et al. Methods Mol Biol. 2016;1377:19-27. doi: 10.1007/978-1-4939-3179-8_4. Methods Mol Biol. 2016. PMID: 26695019
Gastric H(+),K(+)-ATPase is an ATP-driven proton pump responsible for the acid secretion. Here, we describe the procedure for the isolation of H(+),K(+)-ATPase-enriched membrane vesicle fractions by Ficoll/sucrose density gradient centrifugation. ...
Gastric H(+),K(+)-ATPase is an ATP-driven proton pump responsible for the acid secretion. Here, we describe the procedure for the iso …
4,708 results