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A novel fully-human cytolytic fusion protein based on granzyme B shows in vitro cytotoxicity and ex vivo binding to solid tumors overexpressing the epidermal growth factor receptor.
Cancer Lett. 2016 May 1;374(2):229-40. doi: 10.1016/j.canlet.2016.02.020. Epub 2016 Feb 18.
Cancer Lett. 2016.
PMID: 26912070
Novel EGFR-specific immunotoxins based on panitumumab and cetuximab show in vitro and ex vivo activity against different tumor entities.
Niesen J, Stein C, Brehm H, Hehmann-Titt G, Fendel R, Melmer G, Fischer R, Barth S.
Niesen J, et al. Among authors: hehmann titt g.
J Cancer Res Clin Oncol. 2015 Dec;141(12):2079-95. doi: 10.1007/s00432-015-1975-5. Epub 2015 Apr 22.
J Cancer Res Clin Oncol. 2015.
PMID: 25899161
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Targeted ex vivo reduction of CD64-positive monocytes in chronic myelomonocytic leukemia and acute myelomonocytic leukemia using human granzyme B-based cytolytic fusion proteins.
Schiffer S, Rosinke R, Jost E, Hehmann-Titt G, Huhn M, Melmer G, Barth S, Thepen T.
Schiffer S, et al. Among authors: hehmann titt g.
Int J Cancer. 2014 Sep 15;135(6):1497-508. doi: 10.1002/ijc.28786. Epub 2014 Mar 18.
Int J Cancer. 2014.
PMID: 24523193
Free article.
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