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TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease.
Tang Q, Markby GR, MacNair AJ, Tang K, Tkacz M, Parys M, Phadwal K, MacRae VE, Corcoran BM. Tang Q, et al. Among authors: markby gr. Cell Prolif. 2023 Jun;56(6):e13435. doi: 10.1111/cpr.13435. Epub 2023 Mar 4. Cell Prolif. 2023. PMID: 36869852 Free PMC article.
Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice.
Roberts FL, Rashdan NA, Phadwal K, Markby GR, Dillon S, Zoll J, Berger J, Milne E, Orriss IR, Karsenty G, Le Saux O, Morton NM, Farquharson C, MacRae VE. Roberts FL, et al. Among authors: markby gr. J Cell Physiol. 2021 Jun;236(6):4614-4624. doi: 10.1002/jcp.30194. Epub 2020 Dec 10. J Cell Physiol. 2021. PMID: 33305372 Free PMC article.