Gordon J. Lockbaum - Search Results

Year	Number of Results
2018	2
2019	5
2020	3
2021	5
2022	2
2023	2
2024	0

1

Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.

Matthew AN, Leidner F, Lockbaum GJ, Henes M, Zephyr J, Hou S, Rao DN, Timm J, Rusere LN, Ragland DA, Paulsen JL, Prachanronarong K, Soumana DI, Nalivaika EA, Kurt Yilmaz N, Ali A, Schiffer CA. Matthew AN, et al. Among authors: lockbaum gj. Chem Rev. 2021 Mar 24;121(6):3238-3270. doi: 10.1021/acs.chemrev.0c00648. Epub 2021 Jan 7. Chem Rev. 2021. PMID: 33410674 Free PMC article. Review.

2

Inhibiting HTLV-1 Protease: A Viable Antiviral Target.

Lockbaum GJ, Henes M, Talledge N, Rusere LN, Kosovrasti K, Nalivaika EA, Somasundaran M, Ali A, Mansky LM, Kurt Yilmaz N, Schiffer CA. Lockbaum GJ, et al. ACS Chem Biol. 2021 Mar 19;16(3):529-538. doi: 10.1021/acschembio.0c00975. Epub 2021 Feb 23. ACS Chem Biol. 2021. PMID: 33619959 Free PMC article.

3

Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.

Shaqra AM, Zvornicanin SN, Huang QYJ, Lockbaum GJ, Knapp M, Tandeske L, Bakan DT, Flynn J, Bolon DNA, Moquin S, Dovala D, Kurt Yilmaz N, Schiffer CA. Shaqra AM, et al. Among authors: lockbaum gj. Nat Commun. 2022 Jun 21;13(1):3556. doi: 10.1038/s41467-022-31210-w. Nat Commun. 2022. PMID: 35729165 Free PMC article.

4

Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance.

Spielvogel E, Lee SK, Zhou S, Lockbaum GJ, Henes M, Sondgeroth A, Kosovrasti K, Nalivaika EA, Ali A, Yilmaz NK, Schiffer CA, Swanstrom R. Spielvogel E, et al. Among authors: lockbaum gj. Elife. 2023 Mar 15;12:e80328. doi: 10.7554/eLife.80328. Elife. 2023. PMID: 36920025 Free PMC article.

5

Dual Inhibitors of Main Protease (M^Pro) and Cathepsin L as Potent Antivirals against SARS-CoV2.

Mondal S, Chen Y, Lockbaum GJ, Sen S, Chaudhuri S, Reyes AC, Lee JM, Kaur AN, Sultana N, Cameron MD, Shaffer SA, Schiffer CA, Fitzgerald KA, Thompson PR. Mondal S, et al. Among authors: lockbaum gj. J Am Chem Soc. 2022 Nov 23;144(46):21035-21045. doi: 10.1021/jacs.2c04626. Epub 2022 Nov 10. J Am Chem Soc. 2022. PMID: 36356199 Free PMC article.

6

Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode.

Lockbaum GJ, Henes M, Lee JM, Timm J, Nalivaika EA, Thompson PR, Kurt Yilmaz N, Schiffer CA. Lockbaum GJ, et al. Biochemistry. 2021 Oct 5;60(39):2925-2931. doi: 10.1021/acs.biochem.1c00414. Epub 2021 Sep 10. Biochemistry. 2021. PMID: 34506130

7

Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188.

Lockbaum GJ, Reyes AC, Lee JM, Tilvawala R, Nalivaika EA, Ali A, Kurt Yilmaz N, Thompson PR, Schiffer CA. Lockbaum GJ, et al. Viruses. 2021 Jan 25;13(2):174. doi: 10.3390/v13020174. Viruses. 2021. PMID: 33503819 Free PMC article.

8

Unique structural solution from a V_H3-30 antibody targeting the hemagglutinin stem of influenza A viruses.

Harshbarger WD, Deming D, Lockbaum GJ, Attatippaholkun N, Kamkaew M, Hou S, Somasundaran M, Wang JP, Finberg RW, Zhu QK, Schiffer CA, Marasco WA. Harshbarger WD, et al. Among authors: lockbaum gj. Nat Commun. 2021 Jan 25;12(1):559. doi: 10.1038/s41467-020-20879-6. Nat Commun. 2021. PMID: 33495478 Free PMC article.

9

Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.

Lockbaum GJ, Leidner F, Rusere LN, Henes M, Kosovrasti K, Nachum GS, Nalivaika EA, Ali A, Yilmaz NK, Schiffer CA. Lockbaum GJ, et al. ACS Infect Dis. 2019 Feb 8;5(2):316-325. doi: 10.1021/acsinfecdis.8b00336. Epub 2018 Dec 31. ACS Infect Dis. 2019. PMID: 30543749 Free PMC article.

10

HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues.

Lockbaum GJ, Rusere LN, Henes M, Kosovrasti K, Rao DN, Spielvogel E, Lee SK, Nalivaika EA, Swanstrom R, Yilmaz NK, Schiffer CA, Ali A. Lockbaum GJ, et al. Eur J Med Chem. 2023 Sep 5;257:115501. doi: 10.1016/j.ejmech.2023.115501. Epub 2023 May 18. Eur J Med Chem. 2023. PMID: 37244161

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