We demonstrate the first integrated transmitter for serial 100 Gb/s NRZ-OOK modulation in datacom and telecom applications. The transmitter relies on the use of an electro-optic polymer modulator and the hybrid integration of an InP laser diode and InP-DHBT electronics with the polymer board. Evaluation is made at 80 and 100 Gb/s through eye-diagrams and BER measurements using a receiver module that integrates a pin-photodiode and an electrical 1:2 demultiplexer. Error-free performance is confirmed both at 80 and 100 Gb/s revealing the viability of the approach and the potential of the technology.