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Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal.
Distler MG, Plant LD, Sokoloff G, Hawk AJ, Aneas I, Wuenschell GE, Termini J, Meredith SC, Nobrega MA, Palmer AA. Distler MG, et al. Among authors: wuenschell ge. J Clin Invest. 2012 Jun;122(6):2306-15. doi: 10.1172/JCI61319. Epub 2012 May 15. J Clin Invest. 2012. PMID: 22585572 Free PMC article.