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Expression of protein kinase C gamma promotes cell migration in colon cancer.
Dowling CM, Hayes SL, Phelan JJ, Cathcart MC, Finn SP, Mehigan B, McCormick P, Coffey JC, O'sullivan J, Kiely PA. Dowling CM, et al. Oncotarget. 2017 Jul 1;8(42):72096-72107. doi: 10.18632/oncotarget.18916. eCollection 2017 Sep 22. Oncotarget. 2017. PMID: 29069771 Free PMC article.
One of the PKC isozymes, PKC gamma, is thought to be present only in the brain and has been largely neglected in the context of cancer. Analysis of gene expression levels of PKC gamma in patient matched normal and colon cancer tissue samples revealed an up-regulation of th …
One of the PKC isozymes, PKC gamma, is thought to be present only in the brain and has been largely neglected in the context of cancer. Anal …
Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival.
Dowling CM, Phelan J, Callender JA, Cathcart MC, Mehigan B, McCormick P, Dalton T, Coffey JC, Newton AC, O'Sullivan J, Kiely PA. Dowling CM, et al. Oncotarget. 2016 Apr 12;7(15):20919-33. doi: 10.18632/oncotarget.8062. Oncotarget. 2016. PMID: 26989024 Free PMC article.
Here we examine colon cancer patients and show not only that PKC Beta II is a tumour suppressor, but patients with low levels of this isozyme have significantly decreased disease free survival. Specifically, analysis of gene expression levels of all PKC genes in mat …
Here we examine colon cancer patients and show not only that PKC Beta II is a tumour suppressor, but patients with low levels of this isozym …
Mismatch repair, p53 and chromosomal aberrations in primary colorectal carcinomas.
Mehigan BJ, Ashman JN, Baker RP, Macdonald A, Greenman J, Monson JR, Cawkwell L. Mehigan BJ, et al. Acta Oncol. 2006;45(1):61-6. doi: 10.1080/02841860500374463. Acta Oncol. 2006. PMID: 16464797
Microsatellite instability, due to defective mismatch repair genes, characterizes one pathway and gross chromosomal instability another. The involvement of p53 and mismatch repair gene abnormalities within these pathways has not been fully explored. ...
Microsatellite instability, due to defective mismatch repair genes, characterizes one pathway and gross chromosomal instability anoth …