Fluoride Status and Cardiometabolic Health: Findings from a Representative Survey among Children and Adolescents

Nutrients. 2022 Mar 31;14(7):1459. doi: 10.3390/nu14071459.

Abstract

There is preliminary evidence to suggest a positive association between fluoride exposure and higher blood pressure among children, but population-based biomarker studies are lacking. Thus, data from the 2013/2014 and 2015/2016 cycles of the US-based National Health and Nutrition Examination Survey (NHANES) were analysed to evaluate the association between plasma fluoride concentrations and blood pressure among children and adolescents aged 8 to 19 years. Secondary analyses were carried out on fluoride status in relation to further markers of cardio-metabolic health, i.e., anthropometric indices, biomarkers of lipid and sugar metabolism, and C-reactive protein levels. There was a positive correlation between water fluoride content and plasma fluoride concentrations (Spearman’s r = 0.41, p < 0.01). However, multivariable linear regression models did not show significant differences in adjusted mean values of systolic and diastolic blood pressure across increasing quartiles of fluoride concentrations. Further markers of cardio-metabolic health were not associated with fluoride status, with the exception of a weak inverse association between plasma fluoride and HbA1c levels. Higher plasma fluoride may not be a risk factor for increased blood pressure or impaired cardio-metabolic health among children in the USA, a non-fluoride endemic country, with wide-spread water fluoridation.

Keywords: C-reactive protein; CRP; HbA1c; NHANES; adolescents; blood pressure; children; fluoride; lipids.

MeSH terms

  • Adolescent
  • Anthropometry
  • Cardiovascular Diseases* / epidemiology
  • Child
  • Fluorides* / adverse effects
  • Humans
  • Nutrition Surveys
  • Risk Factors

Substances

  • Fluorides