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The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT).
Pharaoh G, Kamat V, Kannan S, Stuppard RS, Whitson J, Martín-Pérez M, Qian WJ, MacCoss MJ, Villén J, Rabinovitch P, Campbell MD, Sweet IR, Marcinek DJ. Pharaoh G, et al. Geroscience. 2023 Dec;45(6):3529-3548. doi: 10.1007/s11357-023-00861-y. Epub 2023 Jul 18. Geroscience. 2023. PMID: 37462785 Free PMC article.
Cancer cachexia in a mouse model of oxidative stress.
Brown JL, Lawrence MM, Ahn B, Kneis P, Piekarz KM, Qaisar R, Ranjit R, Bian J, Pharaoh G, Brown C, Peelor FF 3rd, Kinter MT, Miller BF, Richardson A, Van Remmen H. Brown JL, et al. Among authors: pharaoh g. J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1688-1704. doi: 10.1002/jcsm.12615. Epub 2020 Sep 12. J Cachexia Sarcopenia Muscle. 2020. PMID: 32918528 Free PMC article.
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