Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

Nat Commun. 2022 Feb 8;13(1):751. doi: 10.1038/s41467-021-27942-w.

Abstract

Understanding SARS-CoV-2 transmission in higher education settings is important to limit spread between students, and into at-risk populations. In this study, we sequenced 482 SARS-CoV-2 isolates from the University of Cambridge from 5 October to 6 December 2020. We perform a detailed phylogenetic comparison with 972 isolates from the surrounding community, complemented with epidemiological and contact tracing data, to determine transmission dynamics. We observe limited viral introductions into the university; the majority of student cases were linked to a single genetic cluster, likely following social gatherings at a venue outside the university. We identify considerable onward transmission associated with student accommodation and courses; this was effectively contained using local infection control measures and following a national lockdown. Transmission clusters were largely segregated within the university or the community. Our study highlights key determinants of SARS-CoV-2 transmission and effective interventions in a higher education setting that will inform public health policy during pandemics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19 / epidemiology*
  • COVID-19 / prevention & control
  • COVID-19 / transmission*
  • COVID-19 / virology
  • Contact Tracing
  • Genome, Viral / genetics
  • Genomics
  • Humans
  • Phylogeny
  • RNA, Viral / genetics
  • Risk Factors
  • SARS-CoV-2 / classification
  • SARS-CoV-2 / genetics*
  • SARS-CoV-2 / isolation & purification
  • Students
  • United Kingdom / epidemiology
  • Universities* / statistics & numerical data

Substances

  • RNA, Viral