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The following term was not found in PubMed: Pamerneckyte
Page 1
Structural basis of Gabija anti-phage defence and viral immune evasion.
Antine SP, Johnson AG, Mooney SE, Leavitt A, Mayer ML, Yirmiya E, Amitai G, Sorek R, Kranzusch PJ. Antine SP, et al. Nature. 2024 Jan;625(7994):360-365. doi: 10.1038/s41586-023-06855-2. Epub 2023 Nov 22. Nature. 2024. PMID: 37992757 Free PMC article.
Gabija protein A (GajA) is a DNA endonuclease that tetramerizes to form the core of the anti-phage defence complex. ...We show that a phage-encoded protein, Gabija anti-defence 1 (Gad1), directly binds to the Gabija GajAB complex and inactivates defence. ...
Gabija protein A (GajA) is a DNA endonuclease that tetramerizes to form the core of the anti-phage defence complex. ...We show that a …
Phages overcome bacterial immunity via diverse anti-defence proteins.
Yirmiya E, Leavitt A, Lu A, Ragucci AE, Avraham C, Osterman I, Garb J, Antine SP, Mooney SE, Hobbs SJ, Kranzusch PJ, Amitai G, Sorek R. Yirmiya E, et al. Nature. 2024 Jan;625(7994):352-359. doi: 10.1038/s41586-023-06869-w. Epub 2023 Nov 22. Nature. 2024. PMID: 37992756
Here we analysed groups of closely related Bacillus phages that showed differential sensitivity to bacterial defence systems, and discovered four distinct families of anti-defence proteins that inhibit the Gabija, Thoeris and Hachiman systems. We show that these proteins G …
Here we analysed groups of closely related Bacillus phages that showed differential sensitivity to bacterial defence systems, and discovered …
Structures and activation mechanism of the Gabija anti-phage system.
Li J, Cheng R, Wang Z, Yuan W, Xiao J, Zhao X, Du X, Xia S, Wang L, Zhu B, Wang L. Li J, et al. Nature. 2024 Mar 12. doi: 10.1038/s41586-024-07270-x. Online ahead of print. Nature. 2024. PMID: 38471529
Prokaryotes have evolved intricate innate immune systems against phage infection(1-7). Gabija is a highly widespread prokaryotic defence system that consists of two components, GajA and GajB(8). ...GajB, which docks on GajA, is activated by the cleaved DNA, ultimately lead …
Prokaryotes have evolved intricate innate immune systems against phage infection(1-7). Gabija is a highly widespread prokaryotic defe …
A nucleotide-sensing endonuclease from the Gabija bacterial defense system.
Cheng R, Huang F, Wu H, Lu X, Yan Y, Yu B, Wang X, Zhu B. Cheng R, et al. Nucleic Acids Res. 2021 May 21;49(9):5216-5229. doi: 10.1093/nar/gkab277. Nucleic Acids Res. 2021. PMID: 33885789 Free PMC article.
Here, we report functional analyses of the GajA protein from the newly predicted Gabija system. The GajA protein is revealed as a sequence-specific DNA nicking endonuclease unique in that its activity is strictly regulated by nucleotide concentration. ...Interestingly, the …
Here, we report functional analyses of the GajA protein from the newly predicted Gabija system. The GajA protein is revealed as a seq …
Prokaryotic Gabija complex senses and executes nucleotide depletion and DNA cleavage for antiviral defense.
Cheng R, Huang F, Lu X, Yan Y, Yu B, Wang X, Zhu B. Cheng R, et al. Cell Host Microbe. 2023 Aug 9;31(8):1331-1344.e5. doi: 10.1016/j.chom.2023.06.014. Epub 2023 Jul 21. Cell Host Microbe. 2023. PMID: 37480847
The Gabija complex is a prokaryotic antiviral system consisting of the GajA and GajB proteins. ...However, a functional Gabija complex requires a molecular ratio between GajB and GajA below 1:1, indicating stoichiometric regulation of the DNA/nucleotide processing c …
The Gabija complex is a prokaryotic antiviral system consisting of the GajA and GajB proteins. ...However, a functional Gabija …
Structural and functional investigation of GajB protein in Gabija anti-phage defense.
Oh H, Koo J, An SY, Hong SH, Suh JY, Bae E. Oh H, et al. Nucleic Acids Res. 2023 Nov 27;51(21):11941-11951. doi: 10.1093/nar/gkad951. Nucleic Acids Res. 2023. PMID: 37897358 Free PMC article.
To fend off invading phages, the hosts have evolved a variety of anti-phage defense mechanisms. Gabija is one of the most abundant prokaryotic antiviral systems and consists of two proteins, GajA and GajB. ...We demonstrated that GajB interacts with GajA to form a heterooc …
To fend off invading phages, the hosts have evolved a variety of anti-phage defense mechanisms. Gabija is one of the most abundant pr …
Bacterial defense systems exhibit synergistic anti-phage activity.
Wu Y, Garushyants SK, van den Hurk A, Aparicio-Maldonado C, Kushwaha SK, King CM, Ou Y, Todeschini TC, Clokie MRJ, Millard AD, Gençay YE, Koonin EV, Nobrega FL. Wu Y, et al. Cell Host Microbe. 2024 Apr 10;32(4):557-572.e6. doi: 10.1016/j.chom.2024.01.015. Epub 2024 Feb 22. Cell Host Microbe. 2024. PMID: 38402614 Free article.
Notably, Zorya II synergizes with Druantia III and ietAS defense systems, while tmn exhibits synergy with co-occurring systems Gabija, Septu I, and PrrC. For Gabija, tmn co-opts the sensory switch ATPase domain, enhancing anti-phage activity. ...
Notably, Zorya II synergizes with Druantia III and ietAS defense systems, while tmn exhibits synergy with co-occurring systems Gabija …
Molecular basis of Gabija anti-phage supramolecular assemblies.
Yang XY, Shen Z, Xie J, Greenwald J, Marathe I, Lin Q, Xie WJ, Wysocki VH, Fu TM. Yang XY, et al. Nat Struct Mol Biol. 2024 Apr 16. doi: 10.1038/s41594-024-01283-w. Online ahead of print. Nat Struct Mol Biol. 2024. PMID: 38627580
As one of the most prevalent anti-phage defense systems in prokaryotes, Gabija consists of a Gabija protein A (GajA) and a Gabija protein B (GajB). The assembly and function of the Gabija system remain unclear. Here we present cryo-EM structures of Bac …
As one of the most prevalent anti-phage defense systems in prokaryotes, Gabija consists of a Gabija protein A (GajA) and a …
OLD family nuclease function across diverse anti-phage defense systems.
Akritidou K, Thurtle-Schmidt BH. Akritidou K, et al. Front Microbiol. 2023 Sep 28;14:1268820. doi: 10.3389/fmicb.2023.1268820. eCollection 2023. Front Microbiol. 2023. PMID: 37840731 Free PMC article. Review.
Despite being discovered over 50 years ago, OLD nuclease function remained mysterious until recent biochemical, structural, and bioinformatic studies revealed that OLD nucleases protect bacteria by functioning in diverse anti-phage defense systems including the Gabija syst …
Despite being discovered over 50 years ago, OLD nuclease function remained mysterious until recent biochemical, structural, and bioinformati …
Landscape of New Nuclease-Containing Antiphage Systems in Escherichia coli and the Counterdefense Roles of Bacteriophage T4 Genome Modifications.
Wang S, Sun E, Liu Y, Yin B, Zhang X, Li M, Huang Q, Tan C, Qian P, Rao VB, Tao P. Wang S, et al. J Virol. 2023 Jun 29;97(6):e0059923. doi: 10.1128/jvi.00599-23. Epub 2023 Jun 12. J Virol. 2023. PMID: 37306585 Free PMC article.
Our analysis identified at least 17 nuclease-containing defense systems in E. coli, with type III Druantia being the most abundant system, followed by Zorya, Septu, Gabija, AVAST type 4, and qatABCD. Of these, 8 nuclease-containing systems were found to be active against p …
Our analysis identified at least 17 nuclease-containing defense systems in E. coli, with type III Druantia being the most abundant system, f …
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