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Analyzing proteolytic stability and metabolic hotspots of therapeutic peptides in two rodent pulmonary fluids.
Wesche F, De Maria L, Leek T, Narjes F, Bird J, Su W, Czechtizky W. Wesche F, et al. J Pharm Biomed Anal. 2023 Feb 5;224:115156. doi: 10.1016/j.jpba.2022.115156. Epub 2022 Nov 19. J Pharm Biomed Anal. 2023. PMID: 36463768
Comparison of our experimental results and literature-derived cleavage site estimates based on e.g. MEROPS show significant differences for a number of peptides. ...
Comparison of our experimental results and literature-derived cleavage site estimates based on e.g. MEROPS show significant differenc …
Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase.
Harper S, Avolio S, Pacini B, Di Filippo M, Altamura S, Tomei L, Paonessa G, Di Marco S, Carfi A, Giuliano C, Padron J, Bonelli F, Migliaccio G, De Francesco R, Laufer R, Rowley M, Narjes F. Harper S, et al. J Med Chem. 2005 Jul 14;48(14):4547-57. doi: 10.1021/jm050056+. J Med Chem. 2005. PMID: 15999993
Compounds that block replication of subgenomic HCV RNA in liver cells are of interest because of their demonstrated antiviral effect in the clinic. In followup to our recent report that indole-N-acetamides (e.g., 1) are potent allosteric inhibitors of the HCV NS5B polymera …
Compounds that block replication of subgenomic HCV RNA in liver cells are of interest because of their demonstrated antiviral effect in the …
Hair mercury concentrations of lactating mothers and breastfed infants in Iran (fish consumption and mercury exposure).
Okati N, Sari AE, Ghasempouri SM. Okati N, et al. Biol Trace Elem Res. 2012 Nov;149(2):155-62. doi: 10.1007/s12011-012-9424-7. Epub 2012 May 17. Biol Trace Elem Res. 2012. PMID: 22592844
The mean of mercury concentration in the hair of 93 pairs of mothers and infants was obtained and was 3.55 and 1.89 mug g(-1), respectively. A statistically significant correlation (R = 0.850, P = 0.000) was seen between mercury concentration in the hair of mothers and inf …
The mean of mercury concentration in the hair of 93 pairs of mothers and infants was obtained and was 3.55 and 1.89 mug g(-1), respec …