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Enhancing chemical and physical stability of pharmaceuticals using freeze-thaw method: challenges and opportunities for process optimization through quality by design approach.
Bernal-Chávez SA, Romero-Montero A, Hernández-Parra H, Peña-Corona SI, Del Prado-Audelo ML, Alcalá-Alcalá S, Cortés H, Kiyekbayeva L, Sharifi-Rad J, Leyva-Gómez G. Bernal-Chávez SA, et al. J Biol Eng. 2023 May 23;17(1):35. doi: 10.1186/s13036-023-00353-9. J Biol Eng. 2023. PMID: 37221599 Free PMC article. Review.
The freeze-thaw (F/T) method is commonly employed during the processing and handling of drug substances to enhance their chemical and physical stability and obtain pharmaceutical applications such as hydrogels, emulsions, and nanosystems (e.g., supramolecular complexes of …
The freeze-thaw (F/T) method is commonly employed during the processing and handling of drug substances to enhance their chemical and physic …
Antioxidant potential of family Cucurbitaceae with special emphasis on Cucurbita genus: A key to alleviate oxidative stress-mediated disorders.
Salehi B, Quispe C, Sharifi-Rad J, Giri L, Suyal R, Jugran AK, Zucca P, Rescigno A, Peddio S, Bobiş O, Moise AR, Leyva-Gómez G, Del Prado-Audelo ML, Cortes H, Iriti M, Martorell M, Cruz-Martins N, Kumar M, Zam W. Salehi B, et al. Phytother Res. 2021 Jul;35(7):3533-3557. doi: 10.1002/ptr.7045. Epub 2021 Feb 16. Phytother Res. 2021. PMID: 33590924 Review.
Combined use of novel chitosan-grafted N-hydroxyethyl acrylamide polyurethane and human dermal fibroblasts as a construct for in vitro-engineered skin.
González-Torres M, Elizalde-Cárdenas A, Leyva-Gómez G, González-Mendoza O, Lima E, Núñez-Tapia I, Abad-Contreras DE, Luisa Del Prado-Audelo M, Pichardo-Bahena R, Carlos-Martínez A, Ribas-Aparicio RM. González-Torres M, et al. Int J Biol Macromol. 2023 May 31;238:124136. doi: 10.1016/j.ijbiomac.2023.124136. Epub 2023 Mar 23. Int J Biol Macromol. 2023. PMID: 36965555
The capability of CS-grafted poly(N-hydroxyethyl acrylamide) (CS-g-PHEAA) to support human dermal fibroblasts (HDFs) in vitro has been proven. ...This study aimed to show for the first time that step-growth polymerizations can be used to obtain polyurethane (PU) platforms …
The capability of CS-grafted poly(N-hydroxyethyl acrylamide) (CS-g-PHEAA) to support human dermal fibroblasts (HDFs) in vitro has bee …
Inhibition of proliferation, migration, and adhesion of skin fibroblasts by enzymatic poly(gallic acid) grafted with L-Arginine, migration, and adhesion of skin fibroblasts by enzymatic poly(gallic acid) grafted with L-Arginine.
Ortega-Sánchez C, Pérez-Díaz MA, Martínez-López V, Zacaula-Juárez N, González-Torres M, Leyva-Gómez G, Hernandez-Valdepeña MA, Gimeno M, Sánchez-Sánchez R. Ortega-Sánchez C, et al. Cell Mol Biol (Noisy-le-grand). 2023 Jan 31;69(1):1-6. doi: 10.14715/cmb/2022.69.1.1. Cell Mol Biol (Noisy-le-grand). 2023. PMID: 37213165
The search for new molecules for therapeutic skin treatment mainly focuses on the antioxidant and anti-inflammatory properties, highlighting the rheological properties of polymeric polypeptides. We studied L-arginine (L-Arg) grafted (-g-) to enzymatic poly(gallic acid) (PG …
The search for new molecules for therapeutic skin treatment mainly focuses on the antioxidant and anti-inflammatory properties, highlighting …
Association of TLR4 gene polymorphisms with sepsis after a burn injury: findings of the functional role of rs2737190 SNP.
Colín-Castro CA, Franco-Cendejas R, Rocha-González HI, Cruz-Arenas E, Leyva-García N, Sánchez-Sánchez R, Leyva-Gomez G, Gómez R, Muñoz B, Cortés H, Magaña JJ. Colín-Castro CA, et al. Genes Immun. 2021 May;22(1):24-34. doi: 10.1038/s41435-021-00121-z. Epub 2021 Feb 2. Genes Immun. 2021. PMID: 33531683
We found that the rs2737190 polymorphism is associated with sepsis after burn trauma. Interestingly, the G allele and GG genotype were associated with a lower risk of developing sepsis. ...
We found that the rs2737190 polymorphism is associated with sepsis after burn trauma. Interestingly, the G allele and GG genotype wer …
Gamma radiation-induced grafting of poly(2-aminoethyl methacrylate) onto chitosan: A comprehensive study of a polyurethane scaffold intended for skin tissue engineering.
González-Torres M, Serrano-Aguilar IH, Cabrera-Wrooman A, Sánchez-Sánchez R, Pichardo-Bahena R, Melgarejo-Ramírez Y, Leyva-Gómez G, Cortés H, de Los Angeles Moyaho-Bernal M, Lima E, Ibarra C, Velasquillo C. González-Torres M, et al. Carbohydr Polym. 2021 Oct 15;270:117916. doi: 10.1016/j.carbpol.2021.117916. Epub 2021 Mar 5. Carbohydr Polym. 2021. PMID: 34364636
A novel brush-like poly(2-aminoethyl methacrylate) (PAEMA) was grafted onto chitosan (CS) through gamma radiation-induced polymerization. The copolymer (CS-g-PAEMA) was used to prepare a sodium acetate leached poly(urethane-urea) scaffold. ...The results revealed that this …
A novel brush-like poly(2-aminoethyl methacrylate) (PAEMA) was grafted onto chitosan (CS) through gamma radiation-induced polymerization. Th …
Preparation of xyloglucan-grafted poly(N-hydroxyethyl acrylamide) copolymer by free-radical polymerization for in vitro evaluation of human dermal fibroblasts.
González-Torres M, Martínez-Mata R, Ruvalcaba-Paredes EK, Del Real A, Leyva-Gómez G, Maciel-Cerda A. González-Torres M, et al. J Mater Sci Mater Med. 2024 Mar 25;35(1):20. doi: 10.1007/s10856-024-06783-1. J Mater Sci Mater Med. 2024. PMID: 38526669 Free PMC article.
Gamma radiation-induced graft polymerization was employed as an initiator by varying the radiation dose from 5-25 kGy. The structure of the graft copolymer, Xy-g-poly(N-hydroxyethyl acrylamide), was verified by thermal analysis, Fourier transform infrared spectroscopy, and …
Gamma radiation-induced graft polymerization was employed as an initiator by varying the radiation dose from 5-25 kGy. The structure of the …
Effects of UV-C and Edible Nano-Coating as a Combined Strategy to Preserve Fresh-Cut Cucumber.
Zambrano-Zaragoza ML, Quintanar-Guerrero D, González-Reza RM, Cornejo-Villegas MA, Leyva-Gómez G, Urbán-Morlán Z. Zambrano-Zaragoza ML, et al. Polymers (Basel). 2021 Oct 27;13(21):3705. doi: 10.3390/polym13213705. Polymers (Basel). 2021. PMID: 34771260 Free PMC article.
In contrast, with combined UV-C and nano-coating treatment, the amount of polyphenols was reduced by 38.84% within 15 days. The antioxidant capacity remained stable at 459 mumol TE/100 g for the fresh product when the combined treatment was used. A good correlation was als …
In contrast, with combined UV-C and nano-coating treatment, the amount of polyphenols was reduced by 38.84% within 15 days. The antioxidant …
Coexistence of D3 R typical and atypical signaling in striatonigral neurons during dopaminergic denervation. Correlation with D3 nf expression changes.
Campos Campos B, Ávalos-Fuentes A, Piña Leyva C, Sánchez-Zavaleta R, Loya-López S, Rangel-Barajas C, Leyva-Gómez G, Cortés H, Erlij D, Florán B. Campos Campos B, et al. Synapse. 2020 Aug;74(8):e22152. doi: 10.1002/syn.22152. Epub 2020 Mar 6. Synapse. 2020. PMID: 32068305
The new D(3) R antagonized cAMP accumulation and GABA release stimulated by D(1) R; however, in the presence of N-Ethylmaleimide (NEM), to block G(i) protein signaling, activation of D(3) R produced its atypical signaling stimulating D(1) R effects. ...
The new D(3) R antagonized cAMP accumulation and GABA release stimulated by D(1) R; however, in the presence of N-Ethylmaleimide (NEM), to b …
13 results