DNA methylation aging signatures of multiple metals exposure and their mediation effects in metal-associated mortality: Evidence from the Dongfeng-Tongji cohort study.
Wang C, Zhong G, Liu C, Hong S, Guan X, Xiao Y, Fu M, Zhou Y, You Y, Wu T, Zhao H, Wang Y, Chen S, Zhang Y, Wang C, Guo H.
Wang C, et al.
J Hazard Mater. 2024 Mar 5;465:133200. doi: 10.1016/j.jhazmat.2023.133200. Epub 2023 Dec 10.
J Hazard Mater. 2024.
PMID: 38113735
The Cu, Ni and Sr showed joint positive effects on above three DAIs. PhenoAge-Accel, GrimAge-Accel, and DNAm-MS mediated a separate 6.5%, 12.3%, 6.0% of the positive association between Cu and all-cause mortality; GrimAge-Accel mediated 14.3% of the inverse association of …
The Cu, Ni and Sr showed joint positive effects on above three DAIs. PhenoAge-Accel, GrimAge-Accel, and DNAm-MS mediated a separate 6 …