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Page 1
Effects of Totum-63 on glucose homeostasis and postprandial glycemia: a translational study.
Chavanelle V, Otero YF, Le Joubioux F, Ripoche D, Bargetto M, Vluggens A, Montaurier C, Pickering G, Ducheix G, Dubray C, Dualé C, Boulliau S, Macian N, Marceau G, Sapin V, Dutheil F, Guigas B, Maugard T, Boisseau N, Cazaubiel M, Peltier SL, Sirvent P. Chavanelle V, et al. Among authors: le joubioux f. Am J Physiol Endocrinol Metab. 2021 Jun 1;320(6):E1119-E1137. doi: 10.1152/ajpendo.00629.2020. Epub 2021 May 3. Am J Physiol Endocrinol Metab. 2021. PMID: 33938234 Free PMC article. Clinical Trial.
Totum-070, a Polyphenol-Rich Plant Extract, Prevents Hypercholesterolemia in High-Fat Diet-Fed Hamsters by Inhibiting Intestinal Cholesterol Absorption.
Langhi C, Vallier M, Otero YF, Maura M, Le Joubioux F, Groult H, Achour O, Pebriana RB, Giera M, Guigas B, Maugard T, Chassaing B, Peltier S, Bard JM, Sirvent P. Langhi C, et al. Among authors: le joubioux f. Nutrients. 2023 Dec 9;15(24):5056. doi: 10.3390/nu15245056. Nutrients. 2023. PMID: 38140315 Free PMC article.
Impact of TOTUM-63, a fibre and polyphenol rich plant-based composition, on gut and pancreatic hormone secretion in diet-induced obese mice.
Chavanelle V, Chanon S, Pinteur C, Loizon E, Vial G, Otero YF, Le Joubioux F, Maugard T, Peltier SL, Sirvent P, Morio B. Chavanelle V, et al. Among authors: le joubioux f. Nutr Metab Cardiovasc Dis. 2022 Jul;32(7):1797-1807. doi: 10.1016/j.numecd.2022.04.001. Epub 2022 Apr 22. Nutr Metab Cardiovasc Dis. 2022. PMID: 35618560
TOTUM-63, a plant-based polyphenol-rich extract, improves glycaemic control in subjects with prediabetes or early stage newly-diagnosed type 2 diabetes in a randomized, double-blind, placebo-controlled trial.
Sirvent P, Chavanelle V, Otero YF, Bargetto M, Le Joubioux F, Boisseau N, Maugard T, Cazaubiel M, Pereira B, Guigas B, Hadjadj S, Peltier SL, Marette A, Bard JM. Sirvent P, et al. Among authors: le joubioux f. Diabetes Obes Metab. 2022 Dec;24(12):2331-2340. doi: 10.1111/dom.14817. Epub 2022 Aug 1. Diabetes Obes Metab. 2022. PMID: 35837981 Free PMC article. Clinical Trial.
A polyphenol-rich plant extract prevents hypercholesterolemia and modulates gut microbiota in western diet-fed mice.
Langhi C, Vallier M, Bron A, Otero YF, Maura M, Le Joubioux F, Blomberg N, Giera M, Guigas B, Maugard T, Chassaing B, Peltier S, Blanquet-Diot S, Bard JM, Sirvent P. Langhi C, et al. Among authors: le joubioux f. Front Cardiovasc Med. 2024 Jan 22;11:1342388. doi: 10.3389/fcvm.2024.1342388. eCollection 2024. Front Cardiovasc Med. 2024. PMID: 38317864 Free PMC article.
Effects of a novel polyphenol-rich plant extract on body composition, inflammation, insulin sensitivity, and glucose homeostasis in obese mice.
van der Zande HJP, Lambooij JM, Chavanelle V, Zawistowska-Deniziak A, Otero Y, Otto F, Lantier L, McGuinness OP, Le Joubioux F, Giera M, Maugard T, Peltier SL, Sirvent P, Guigas B. van der Zande HJP, et al. Among authors: le joubioux f. Int J Obes (Lond). 2021 Sep;45(9):2016-2027. doi: 10.1038/s41366-021-00870-x. Epub 2021 Jun 2. Int J Obes (Lond). 2021. PMID: 34079069
The TOTUM-63 Supplement and High-Intensity Interval Training Combination Limits Weight Gain, Improves Glycemic Control, and Influences the Composition of Gut Mucosa-Associated Bacteria in Rats on a High Fat Diet.
Dupuit M, Chavanelle V, Chassaing B, Perriere F, Etienne M, Plissonneau C, Boscaro A, Barnich N, Pialoux V, Maugard T, Le Joubioux F, Peltier S, Sirvent P, Otero YF, Boisseau N. Dupuit M, et al. Among authors: le joubioux f. Nutrients. 2021 May 7;13(5):1569. doi: 10.3390/nu13051569. Nutrients. 2021. PMID: 34066988 Free PMC article.