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A model of human neural networks reveals NPTX2 pathology in ALS and FTLD.
Hruska-Plochan M, Wiersma VI, Betz KM, Mallona I, Ronchi S, Maniecka Z, Hock EM, Tantardini E, Laferriere F, Sahadevan S, Hoop V, Delvendahl I, Pérez-Berlanga M, Gatta B, Panatta M, van der Bourg A, Bohaciakova D, Sharma P, De Vos L, Frontzek K, Aguzzi A, Lashley T, Robinson MD, Karayannis T, Mueller M, Hierlemann A, Polymenidou M. Hruska-Plochan M, et al. Among authors: laferriere f. Nature. 2024 Feb;626(8001):1073-1083. doi: 10.1038/s41586-024-07042-7. Epub 2024 Feb 14. Nature. 2024. PMID: 38355792 Free PMC article.
Neurons with Cat's Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions.
De Giorgi F, Abdul-Shukkoor MB, Kashyrina M, Largitte LA, De Nuccio F, Kauffmann B, Lends A, Laferrière F, Bonhommeau S, Lofrumento DD, Bousset L, Bezard E, Buffeteau T, Loquet A, Ichas F. De Giorgi F, et al. Among authors: laferriere f. Biomolecules. 2022 Mar 11;12(3):436. doi: 10.3390/biom12030436. Biomolecules. 2022. PMID: 35327628 Free PMC article.
Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons.
De Giorgi F, Laferrière F, Zinghirino F, Faggiani E, Lends A, Bertoni M, Yu X, Grélard A, Morvan E, Habenstein B, Dutheil N, Doudnikoff E, Daniel J, Claverol S, Qin C, Loquet A, Bezard E, Ichas F. De Giorgi F, et al. Among authors: laferriere f. Sci Adv. 2020 Oct 2;6(40):eabc4364. doi: 10.1126/sciadv.abc4364. Print 2020 Oct. Sci Adv. 2020. PMID: 33008896 Free PMC article.
19 results