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Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial.
Heerspink HJL, Radhakrishnan J, Alpers CE, Barratt J, Bieler S, Diva U, Inrig J, Komers R, Mercer A, Noronha IL, Rheault MN, Rote W, Rovin B, Trachtman H, Trimarchi H, Wong MG, Perkovic V; PROTECT Investigators. Heerspink HJL, et al. Lancet. 2023 May 13;401(10388):1584-1594. doi: 10.1016/S0140-6736(23)00569-X. Epub 2023 Apr 1. Lancet. 2023. PMID: 37015244 Clinical Trial.
The primary efficacy endpoint was change from baseline to week 36 in urine protein-creatinine ratio based on a 24-h urine sample, assessed using mixed model repeated measures. Treatment-emergent adverse events (TEAEs) were safety endpoints. ...
The primary efficacy endpoint was change from baseline to week 36 in urine protein-creatinine ratio based on a 24-h urine sample, ass …
Proceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016.
Tomás CC, Oliveira E, Sousa D, Uba-Chupel M, Furtado G, Rocha C, Teixeira A, Ferreira P, Alves C, Gisin S, Catarino E, Carvalho N, Coucelo T, Bonfim L, Silva C, Franco D, González JA, Jardim HG, Silva R, Baixinho CL, Presado MªH, Marques MªF, Cardoso ME, Cunha M, Mendes J, Xavier A, Galhardo A, Couto M, Frade JG, Nunes C, Mesquita JR, Nascimento MS, Gonçalves G, Castro C, Mártires A, Monteiro MªJ, Rainho C, Caballero FP, Monago FM, Guerrero JT, Monago RM, Trigo AP, Gutierrez ML, Milanés GM, Reina MG, Villanueva AG, Piñero AS, Aliseda IR, Ramirez FB, Ribeiro A, Quelhas A, Manso C, Caballero FP, Guerrero JT, Monago FM, Santos RB, Jimenez NR, Nuñez CG, Gomez IR, Fernandez MªJL, Marquez LA, Moreno AL, Huertas MªJT, Ramirez FB, Seabra D, Salvador MªC, Braga L, Parreira P, Salgueiro-Oliveira A, Arreguy-Sena C, Oliveira BF, Henriques MªA, Santos J, Lebre S, Marques A, Festas C, Rodrigues S, Ribeiro A, Lumini J, Figueiredo AG, Hernandez-Martinez FJ, Campi L, Quintana-Montesdeoca MªP, Jimenez-Diaz JF, Rodriguez-De-Vera BC, Parente A, Mata MªA, Pereira AMª, Fernandes A, Brás M, Pinto MªR, Parreira P, Basto ML, Rei AC, Mónico LM, Sousa G, Morna C, Freitas O, Freitas G, Jardim A, Vasconcelos … See abstract for full author list ➔ Tomás CC, et al. BMC Health Serv Res. 2016 Jul 6;16 Suppl 3(Suppl 3):200. doi: 10.1186/s12913-016-1423-5. BMC Health Serv Res. 2016. PMID: 27409075 Free PMC article.
Goncalves, Tiago Sales, Ricardo Teixo, Rita Silva, Jessica Estrela, Mafalda Laranjo, Joao Casalta-Lopes, Clara Rocha, Paulo C. ...Lopes, Luis Cavalheiro, Pedro Ferreira, Rui Goncalves P79 Cross-cultural adaptation of the Myocardial Infraction Dimensional Assessment …
Goncalves, Tiago Sales, Ricardo Teixo, Rita Silva, Jessica Estrela, Mafalda Laranjo, Joao Casalta-Lopes, Clara Rocha, Paulo C. ...Lop …
Fungal Planet description sheets: 1042-1111.
Crous PW, Wingfield MJ, Chooi YH, Gilchrist CLM, Lacey E, Pitt JI, Roets F, Swart WJ, Cano-Lira JF, Valenzuela-Lopez N, Hubka V, Shivas RG, Stchigel AM, Holdom DG, Jurjević Ž, Kachalkin AV, Lebel T, Lock C, Martín MP, Tan YP, Tomashevskaya MA, Vitelli JS, Baseia IG, Bhatt VK, Brandrud TE, De Souza JT, Dima B, Lacey HJ, Lombard L, Johnston PR, Morte A, Papp V, Rodríguez A, Rodríguez-Andrade E, Semwal KC, Tegart L, Abad ZG, Akulov A, Alvarado P, Alves A, Andrade JP, Arenas F, Asenjo C, Ballarà J, Barrett MD, Berná LM, Berraf-Tebbal A, Bianchinotti MV, Bransgrove K, Burgess TI, Carmo FS, Chávez R, Čmoková A, Dearnaley JDW, de A Santiago ALCM, Freitas-Neto JF, Denman S, Douglas B, Dovana F, Eichmeier A, Esteve-Raventós F, Farid A, Fedosova AG, Ferisin G, Ferreira RJ, Ferrer A, Figueiredo CN, Figueiredo YF, Reinoso-Fuentealba CG, Garrido-Benavent I, Cañete-Gibas CF, Gil-Durán C, Glushakova AM, Gonçalves MFM, González M, Gorczak M, Gorton C, Guard FE, Guarnizo AL, Guarro J, Gutiérrez M, Hamal P, Hien LT, Hocking AD, Houbraken J, Hunter GC, Inácio CA, Jourdan M, Kapitonov VI, Kelly L, Khanh TN, Kisło K, Kiss L, Kiyashko A, Kolařík M, Kruse J, Kubátová A, Kučera V, Kučerová I, Kušan I, Le… See abstract for full author list ➔ Crous PW, et al. Persoonia. 2020 Jun;44:301-459. doi: 10.3767/persoonia.2020.44.11. Epub 2020 Jun 29. Persoonia. 2020. PMID: 33116344 Free PMC article.
Fungal Planet description sheets: 951-1041.
Crous PW, Wingfield MJ, Lombard L, Roets F, Swart WJ, Alvarado P, Carnegie AJ, Moreno G, Luangsaard J, Thangavel R, Alexandrova AV, Baseia IG, Bellanger JM, Bessette AE, Bessette AR, De la Peña-Lastra S, García D, Gené J, Pham THG, Heykoop M, Malysheva E, Malysheva V, Martín MP, Morozova OV, Noisripoom W, Overton BE, Rea AE, Sewall BJ, Smith ME, Smyth CW, Tasanathai K, Visagie CM, Adamčík S, Alves A, Andrade JP, Aninat MJ, Araújo RVB, Bordallo JJ, Boufleur T, Baroncelli R, Barreto RW, Bolin J, Cabero J, Caboň M, Cafà G, Caffot MLH, Cai L, Carlavilla JR, Chávez R, de Castro RRL, Delgat L, Deschuyteneer D, Dios MM, Domínguez LS, Evans HC, Eyssartier G, Ferreira BW, Figueiredo CN, Liu F, Fournier J, Galli-Terasawa LV, Gil-Durán C, Glienke C, Gonçalves MFM, Gryta H, Guarro J, Himaman W, Hywel-Jones N, Iturrieta-González I, Ivanushkina NE, Jargeat P, Khalid AN, Khan J, Kiran M, Kiss L, Kochkina GA, Kolařík M, Kubátová A, Lodge DJ, Loizides M, Luque D, Manjón JL, Marbach PAS, Massola NS Jr, Mata M, Miller AN, Mongkolsamrit S, Moreau PA, Morte A, Mujic A, Navarro-Ródenas A, Németh MZ, Nóbrega TF, Nováková A, Olariaga I, Ozerskaya SM, Palma MA, Petters-Vandresen DAL, Piontelli E, Popov ES… See abstract for full author list ➔ Crous PW, et al. Persoonia. 2019;43:223-425. doi: 10.3767/persoonia.2019.43.06. Epub 2019 Dec 18. Persoonia. 2019. PMID: 32214501 Free PMC article.
Combined computational and experimental study about the incorporation of phosphorus into the structure of graphene oxide.
Costa TLG, Vieira MA, Gonçalves GR, Cipriano DF, Lacerda V Jr, Gonçalves AS, Scopel WL, de Siervo A, Freitas JCC. Costa TLG, et al. Phys Chem Chem Phys. 2023 Mar 1;25(9):6927-6943. doi: 10.1039/d2cp03666e. Phys Chem Chem Phys. 2023. PMID: 36805087
In this work, an easy route to produce phosphorus-graphene oxide hybrid materials is described, involving the use of variable amounts of H(3)PO(4) and H(2)SO(4) during the reaction of oxidation of a graphitic precursor. ...
In this work, an easy route to produce phosphorus-graphene oxide hybrid materials is described, involving the use of variable amounts of …
Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies.
Pisani L, Algera AG, Neto AS, Azevedo L, Pham T, Paulus F, de Abreu MG, Pelosi P, Dondorp AM, Bellani G, Laffey JG, Schultz MJ; ERICC study investigators; LUNG SAFE study investigators; PRoVENT study investigators; PRoVENT-iMiC study investigators. Pisani L, et al. Lancet Glob Health. 2022 Feb;10(2):e227-e235. doi: 10.1016/S2214-109X(21)00485-X. Epub 2021 Dec 13. Lancet Glob Health. 2022. PMID: 34914899 Free PMC article.
The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5-8] vs 6 [5-8] cm H(2)O; p=0.0011). ICU mortality was higher in MICs than in HICs (30.5% vs 19.9%; p=0.0004; adjusted effect 16.41% [95% CI 9.52-23.52]; p<0.0001) and was inverse …
The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5-8] vs 6 [5-8] cm H(2)O; p=0.0011). ICU m …
Influence of excessive daytime sleepiness on the treatment adherence of obstructive sleep apnea.
Trindade A, Custódio C, Cabral J, Lopes T, Martins V, Aguiar M, Gonçalves I, Furtado S. Trindade A, et al. Sleep Med. 2023 Sep;109:50-55. doi: 10.1016/j.sleep.2023.06.015. Epub 2023 Jun 27. Sleep Med. 2023. PMID: 37418827 Free article.
Patients were divided into two groups according to the adherence to PAP: "Adherent" if using the device for 4 h for 70% of the nights and "Nonadherent" otherwise. Simple and multiple logistic regression models for adherence were determined. ...Most patients had severe OSA …
Patients were divided into two groups according to the adherence to PAP: "Adherent" if using the device for 4 h for 70% of the nights …
Impact of splenic artery ligation after major hepatectomy on liver function, regeneration and viability.
Carrapita J, Abrantes AM, Campelos S, Gonçalves AC, Cardoso D, Sarmento-Ribeiro AB, Rocha C, Santos JN, Botelho MF, Tralhão JG, Farges O, Barbosa JM. Carrapita J, et al. Sci Rep. 2016 Oct 11;6:34731. doi: 10.1038/srep34731. Sci Rep. 2016. PMID: 27725728 Free PMC article.
All methods and experiments were carried out in accordance with Coimbra University guidelines. Splenic artery ligation produces viability increase after 24 h, induces a relative decrease in oxidative stress during the first 48 hours, allows antioxidant capacity increment a …
All methods and experiments were carried out in accordance with Coimbra University guidelines. Splenic artery ligation produces viability in …
Brain TNF drives post-inflammation depression-like behavior and persistent pain in experimental arthritis.
Lopes F, Vicentini FA, Cluny NL, Mathews AJ, Lee BH, Almishri WA, Griffin L, Gonçalves W, Pinho V, McKay DM, Hirota SA, Swain MG, Pittman QJ, Sharkey KA. Lopes F, et al. Brain Behav Immun. 2020 Oct;89:224-232. doi: 10.1016/j.bbi.2020.06.023. Epub 2020 Jun 24. Brain Behav Immun. 2020. PMID: 32592863
Histological damage and elevated levels of cytokines were observed in the knee 24 h after antigen treatment, but not at 13 days. Reduced pain thresholds were seen 24 h and 13 days after treatment. ...Elevated levels of TNF, CCL2, and CXCL-1 were observed in the hipp …
Histological damage and elevated levels of cytokines were observed in the knee 24 h after antigen treatment, but not at 13 days. Redu …
Reduction of the environmental impact of wastewater from the pretreatment of biodiesel production: A hybrid proposal for decontamination via photo-electro-Fenton/Fered/O3.
Kreutz GK, Borba FH, Baroni S, Mayer I, Seibert D, Inticher JJ, Zorzo CF, Guimarães RE. Kreutz GK, et al. J Environ Manage. 2023 Sep 15;342:118080. doi: 10.1016/j.jenvman.2023.118080. Epub 2023 May 15. J Environ Manage. 2023. PMID: 37196625
We performed three new experiments under similar conditions with slight changes to the conditions, namely a longer reaction time (120 min) and single or periodic H(2)O(2) addition (i.e., small H(2)O(2) additions at different reaction times). Periodic H(2)O(2) …
We performed three new experiments under similar conditions with slight changes to the conditions, namely a longer reaction time (120 min) a …
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