Allylation of functionalized aldehydes by potassium allyltrifluoroborate catalyzed by 18-crown-6 in aqueous media

Molecules. 2012 Nov 28;17(12):14099-110. doi: 10.3390/molecules171214099.

Abstract

An efficient method for the allylation of aldehydes containing a broad range of functional groups using potassium allyltrifluoroborate is described. The reaction utilizes a catalytic amount of 18-C-6 in biphasic media under open atmosphere and room temperature to provide the corresponding homoallylic alcohols in high yields and without the necessity of any subsequent purification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Borates / chemistry
  • Catalysis*
  • Crown Ethers / chemistry
  • Potassium / chemistry*
  • Water / chemistry

Substances

  • Aldehydes
  • Borates
  • Crown Ethers
  • Water
  • 18-crown-6
  • fluoroboric acid
  • Potassium