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Page 1
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.
Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, Glynn RJ; CANTOS Trial Group. Ridker PM, et al. N Engl J Med. 2017 Sep 21;377(12):1119-1131. doi: 10.1056/NEJMoa1707914. Epub 2017 Aug 27. N Engl J Med. 2017. PMID: 28845751 Free article. Clinical Trial.
The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P=0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P=0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P=0.031) …
The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P=0 …
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A, Sorice R, Li Y, Taliun D, Olden M, Foster M, Yang Q, Chen MH, Pers TH, Johnson AD, Ko YA, Fuchsberger C, Tayo B, Nalls M, Feitosa MF, Isaacs A, Dehghan A, d'Adamo P, Adeyemo A, Dieffenbach AK, Zonderman AB, Nolte IM, van der Most PJ, Wright AF, Shuldiner AR, Morrison AC, Hofman A, Smith AV, Dreisbach AW, Franke A, Uitterlinden AG, Metspalu A, Tonjes A, Lupo A, Robino A, Johansson Å, Demirkan A, Kollerits B, Freedman BI, Ponte B, Oostra BA, Paulweber B, Krämer BK, Mitchell BD, Buckley BM, Peralta CA, Hayward C, Helmer C, Rotimi CN, Shaffer CM, Müller C, Sala C, van Duijn CM, Saint-Pierre A, Ackermann D, Shriner D, Ruggiero D, Toniolo D, Lu Y, Cusi D, Czamara D, Ellinghaus D, Siscovick DS, Ruderfer D, Gieger C, Grallert H, Rochtchina E, Atkinson EJ, Holliday EG, Boerwinkle E, Salvi E, Bottinger EP, Murgia F, Rivadeneira F, Ernst F, Kronenberg F, Hu FB, Navis GJ, Curhan GC, Ehret GB, Homuth G, Coassin S, Thun GA, Pistis G, Gambaro G, Malerba G, Montgomery GW, Eiriksdottir G, Jacobs G, Li G, Wichmann HE, Campbell H, Schmidt H, Wallaschofski H, Völzke H, Brenner H, Kroemer HK, Kramer H, Lin H, Leach IM, Ford I,… See abstract for full author list ➔ Pattaro C, et al. Nat Commun. 2016 Jan 21;7:10023. doi: 10.1038/ncomms10023. Nat Commun. 2016. PMID: 26831199 Free PMC article.
Early stage litter decomposition across biomes.
Djukic I, Kepfer-Rojas S, Schmidt IK, Larsen KS, Beier C, Berg B, Verheyen K; TeaComposition. Djukic I, et al. Sci Total Environ. 2018 Jul 1;628-629:1369-1394. doi: 10.1016/j.scitotenv.2018.01.012. Epub 2018 Feb 22. Sci Total Environ. 2018. PMID: 30045558 Free article.
High-resolution label-free mapping of murine kidney vasculature by raster-scanning optoacoustic mesoscopy: an ex vivo study.
Goebel CA, Brown E, Fahlbusch FB, Wagner AL, Buehler A, Raupach T, Hohmann M, Späth M, Burton N, Woelfle J, Schmidt M, Hartner A, Regensburger AP, Knieling F. Goebel CA, et al. Mol Cell Pediatr. 2022 Jul 4;9(1):13. doi: 10.1186/s40348-022-00144-0. Mol Cell Pediatr. 2022. PMID: 35788444 Free PMC article.
RESULTS: RSOM enabled mapping of murine kidney size and vascular area, revealing differences between kidney sizes of male (m) and female (f) mice (merged frequencies (MF) f vs. m: 52.426.24 mm(2) vs. 69.1815.96 mm(2), p=0.0156) and absolute vascular area (MF f vs. m: 35.67 …
RESULTS: RSOM enabled mapping of murine kidney size and vascular area, revealing differences between kidney sizes of male (m) and female (f) …
Patients with combined pelvic and spinal injuries have worse clinical and operative outcomes than patients with isolated pelvic injuries analysis of the German Pelvic Registry.
Navas L, Mengis N, Zimmerer A, Rippke JN, Schmidt S, Brunner A, Wagner M, Höch A, Histing T, Herath SC, Küper MA, Ulmar B. Navas L, et al. BMC Musculoskelet Disord. 2022 Mar 15;23(1):251. doi: 10.1186/s12891-022-05193-0. BMC Musculoskelet Disord. 2022. PMID: 35291994 Free PMC article.

RESULTS: Surgery for pelvic fracture was significantly more common in group B than in group A (38.3% vs. 36.6%; p = 0.0002), as also emergency pelvic stabilizations (9.5% vs. 6.7%; p < 0.0001). The mean time to emergency stabilization was longer in group B (137 1

RESULTS: Surgery for pelvic fracture was significantly more common in group B than in group A (38.3% vs. 36.6%; p = 0.0002), as also …
Sports Activity and Patient-Related Outcomes after Cementless Total Hip Arthroplasty in Patients Younger than 40 Years.
Navas L, Faller J, Schmidt S, Streit M, Hauschild M, Zimmerer A. Navas L, et al. J Clin Med. 2021 Oct 10;10(20):4644. doi: 10.3390/jcm10204644. J Clin Med. 2021. PMID: 34682767 Free PMC article.

RESULTS: At the final follow-up, there was a significant improvement in mHHS (34.1 to 92.6; p < 0.0001), UCLA (3.2 to 7.6; p < 0.0001), and VAS for pain (8 to 1; p < 0.0001). More patients were active in sports at follow-up than before surgery (44% t

RESULTS: At the final follow-up, there was a significant improvement in mHHS (34.1 to 92.6; p < 0.0001), UCLA (3.2 to 7.6; p

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
Gorski M, van der Most PJ, Teumer A, Chu AY, Li M, Mijatovic V, Nolte IM, Cocca M, Taliun D, Gomez F, Li Y, Tayo B, Tin A, Feitosa MF, Aspelund T, Attia J, Biffar R, Bochud M, Boerwinkle E, Borecki I, Bottinger EP, Chen MH, Chouraki V, Ciullo M, Coresh J, Cornelis MC, Curhan GC, d'Adamo AP, Dehghan A, Dengler L, Ding J, Eiriksdottir G, Endlich K, Enroth S, Esko T, Franco OH, Gasparini P, Gieger C, Girotto G, Gottesman O, Gudnason V, Gyllensten U, Hancock SJ, Harris TB, Helmer C, Höllerer S, Hofer E, Hofman A, Holliday EG, Homuth G, Hu FB, Huth C, Hutri-Kähönen N, Hwang SJ, Imboden M, Johansson Å, Kähönen M, König W, Kramer H, Krämer BK, Kumar A, Kutalik Z, Lambert JC, Launer LJ, Lehtimäki T, de Borst M, Navis G, Swertz M, Liu Y, Lohman K, Loos RJF, Lu Y, Lyytikäinen LP, McEvoy MA, Meisinger C, Meitinger T, Metspalu A, Metzger M, Mihailov E, Mitchell P, Nauck M, Oldehinkel AJ, Olden M, Wjh Penninx B, Pistis G, Pramstaller PP, Probst-Hensch N, Raitakari OT, Rettig R, Ridker PM, Rivadeneira F, Robino A, Rosas SE, Ruderfer D, Ruggiero D, Saba Y, Sala C, Schmidt H, Schmidt R, Scott RJ, Sedaghat S, Smith AV, Sorice R, Stengel B, Stracke S, Strauch K, Toniolo D, Uitterlinden AG, Ulivi S,… See abstract for full author list ➔ Gorski M, et al. Sci Rep. 2017 Apr 28;7:45040. doi: 10.1038/srep45040. Sci Rep. 2017. PMID: 28452372 Free PMC article.
To investigate the value of such a more complete variant catalog, we conducted a GWAS meta-analysis of kidney function based on the estimated glomerular filtration rate (eGFR) in 110,517 European ancestry participants using 1000 Genomes imputed data. We identified 10 novel loci w …
To investigate the value of such a more complete variant catalog, we conducted a GWAS meta-analysis of kidney function based on the estimate …
In vitro response of THP-1 derived macrophages to antimicrobially effective PHMB-coated Ti6Al4V alloy implant material with and without contamination with S. epidermidis and P. aeruginosa.
Zwicker P, Schmidt T, Hornschuh M, Lode H, Kramer A, Müller G. Zwicker P, et al. Biomater Res. 2022 Jan 9;26(1):1. doi: 10.1186/s40824-021-00247-1. Biomater Res. 2022. PMID: 35000621 Free PMC article.
To preclude an excessive activation of the immune system, possible inflammatory effects on macrophages upon contact with PHMB-coated surfaces alone and after killing of S. epidermidis and P. aeruginosa are analyzed. METHODS: THP-1 monocytes were differentiated to M0 macrop …
To preclude an excessive activation of the immune system, possible inflammatory effects on macrophages upon contact with PHMB-coated surface …
Proteasome inhibition potentiates Kv1.3 potassium channel expression as therapeutic target in drug-sensitive and -resistant human melanoma cells.
Cammann C, Kulla J, Wiebusch L, Walz C, Zhao F, Lowinus T, Topfstedt E, Mishra N, Henklein P, Bommhardt U, Bossaller L, Hagemeier C, Schadendorf D, Schmidt B, Paschen A, Seifert U. Cammann C, et al. Biomed Pharmacother. 2023 Dec;168:115635. doi: 10.1016/j.biopha.2023.115635. Epub 2023 Oct 8. Biomed Pharmacother. 2023. PMID: 37816303 Free article.
Analysis and 3D correction of glenoid dysplasia with metal hemi-wedge base plate augment: short-term radiographic outcomes.
Guehring T, Navas L, Westrich J, Zimmerer A, Schmidt S, Barrientos M, Ulmar B. Guehring T, et al. Arch Orthop Trauma Surg. 2023 Aug;143(8):4763-4772. doi: 10.1007/s00402-023-04781-6. Epub 2023 Jan 27. Arch Orthop Trauma Surg. 2023. PMID: 36705760 Free PMC article.

The mean RSA angle could be corrected from 22.76 6.06 to 0.19 2.7 (p < 0.0001). The highest retroversion of the glenoid is evidenced in the proximal section and it could be corrected from - 23.32 4.56 to - 6.74 7.75 (p < 0.0001) and in the middle section from

The mean RSA angle could be corrected from 22.76 6.06 to 0.19 2.7 (p < 0.0001). The highest retroversion of the glenoid is evidenc

17 results