Solventless lactam synthesis by intramolecular cyclizations of alpha-iminoester derivatives under microwave irradiation

Molecules. 2007 Mar 12;12(3):439-54. doi: 10.3390/12030439.

Abstract

We have previously reported a new synthesis of amides from esters and amines under microwave irradiation, offering much higher yields than those achieved with conventional heating [1]. We have now extended these studies to the ring closure of neat iminoesters I2, I3 and I4-I6 to give five- and six-membered ring lactams L5, L6 and larger lactams L7-L9 (where I means imine and L means lactam), respectively, under both classical heating conditions and microwave irradiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Cyclization
  • Esters / chemistry*
  • Imines / chemistry*
  • Lactams / chemical synthesis*
  • Lactams / chemistry
  • Microwaves*
  • Radiation
  • Solvents / chemistry*
  • Temperature

Substances

  • Esters
  • Imines
  • Lactams
  • Solvents