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Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa.
Soukarieh F, Mashabi A, Richardson W, Oton EV, Romero M, Roberston SN, Grossman S, Sou T, Liu R, Halliday N, Kukavica-Ibrulj I, Levesque RC, Bergstrom CAS, Kellam B, Emsley J, Heeb S, Williams P, Stocks MJ, Cámara M. Soukarieh F, et al. ACS Infect Dis. 2021 Sep 10;7(9):2666-2685. doi: 10.1021/acsinfecdis.1c00175. Epub 2021 Aug 17. ACS Infect Dis. 2021. PMID: 34503335 Free article.
Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system.
Lee JB, Zgair A, Malec J, Kim TH, Kim MG, Ali J, Qin C, Feng W, Chiang M, Gao X, Voronin G, Garces AE, Lau CL, Chan TH, Hume A, McIntosh TM, Soukarieh F, Al-Hayali M, Cipolla E, Collins HM, Heery DM, Shin BS, Yoo SD, Kagan L, Stocks MJ, Bradshaw TD, Fischer PM, Gershkovich P. Lee JB, et al. Among authors: soukarieh f. J Control Release. 2018 Sep 28;286:10-19. doi: 10.1016/j.jconrel.2018.07.022. Epub 2018 Jul 18. J Control Release. 2018. PMID: 30016732 Free PMC article.
Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections.
Soukarieh F, Mashabi A, Richardson W, Oton EV, Romero M, Dubern JF, Robertson SN, Lucanto S, Markham-Lee Z, Sou T, Kukavica-Ibrulj I, Levesque RC, Bergstrom CAS, Halliday N, Kellam B, Emsley J, Heeb S, Williams P, Stocks MJ, Cámara M. Soukarieh F, et al. J Med Chem. 2024 Jan 25;67(2):1008-1023. doi: 10.1021/acs.jmedchem.3c00973. Epub 2024 Jan 3. J Med Chem. 2024. PMID: 38170170 Free PMC article.
Administration in fed state but not controlled release in the colon increases oral bioavailability of DF030263, a promising drug candidate for chronic lymphocytic leukemia.
Lee JB, Zang X, Zgair A, Ooi TQ, Foley DW, Voronin G, Kagan L, Soukarieh F, Gao R, Shao H, Soh WT, Kim TH, Kim MG, Yun HY, Wilson AJ, Fischer PM, Gershkovich P. Lee JB, et al. Among authors: soukarieh f. Eur J Pharm Biopharm. 2021 Aug;165:106-112. doi: 10.1016/j.ejpb.2021.05.006. Epub 2021 May 12. Eur J Pharm Biopharm. 2021. PMID: 33991611
13 results