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Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial.
Anderson CS, Huang Y, Lindley RI, Chen X, Arima H, Chen G, Li Q, Billot L, Delcourt C, Bath PM, Broderick JP, Demchuk AM, Donnan GA, Durham AC, Lavados PM, Lee TH, Levi C, Martins SO, Olavarria VV, Pandian JD, Parsons MW, Pontes-Neto OM, Ricci S, Sato S, Sharma VK, Silva F, Song L, Thang NH, Wardlaw JM, Wang JG, Wang X, Woodward M, Chalmers J, Robinson TG; ENCHANTED Investigators and Coordinators. Anderson CS, et al. Lancet. 2019 Mar 2;393(10174):877-888. doi: 10.1016/S0140-6736(19)30038-8. Epub 2019 Feb 7. Lancet. 2019. PMID: 30739745 Clinical Trial.
Mean systolic blood pressure over 24 h was 144.3 mm Hg (SD 10.2) in the intensive group and 149.8 mm Hg (12.0) in the guideline group (p<0.0001). Primary outcome data were available for 1072 patients in the intensive group and 1108 in the guideline group. Functional sta …
Mean systolic blood pressure over 24 h was 144.3 mm Hg (SD 10.2) in the intensive group and 149.8 mm Hg (12.0) in the guideline group (p …
Ivabradine treatment lowers blood pressure and promotes cardiac and renal protection in spontaneously hypertensive rats.
Gomes FAR, Noronha SISR, Silva SCA, Machado-Júnior PA, Ostolin TLVP, Chírico MTT, Ribeiro MC, Reis AB, Cangussú SD, Montano N, Silva VJD, de Menezes RCA, Silva FC, Chianca-Jr DA. Gomes FAR, et al. Life Sci. 2022 Nov 1;308:120919. doi: 10.1016/j.lfs.2022.120919. Epub 2022 Aug 29. Life Sci. 2022. PMID: 36049530
MAIN METHODS: Rats were divided into 4 groups treated for 14 days with PBS (1 ml/kg; i.p) or IVA (1 mg/kg; i.p): 1) WKY PBS; 2) SHR PBS; 3) WKY IVA; and 4) SHR IVA. ...
MAIN METHODS: Rats were divided into 4 groups treated for 14 days with PBS (1 ml/kg; i.p) or IVA (1 mg/kg; i.p): 1) WKY PBS; 2 …
The accentuation in post-traumatic stress disorder-like symptoms induced by diabetes in rats is not associated with a further increase in astrocyte activation in the hippocampus.
Ribeiro ACAF, Batista TH, Ferrari MS, Giusti-Paiva A, Vilela FC. Ribeiro ACAF, et al. Neurosci Lett. 2021 Sep 25;762:136174. doi: 10.1016/j.neulet.2021.136174. Epub 2021 Aug 13. Neurosci Lett. 2021. PMID: 34400287
For this, we used male Wistar rats and divided them into two groups: saline and alloxan (150 mg/Kg, i.p.). The animals were weighed, and plasma glucose was measured after 48 h of diabetes induction by alloxan. ...
For this, we used male Wistar rats and divided them into two groups: saline and alloxan (150 mg/Kg, i.p.). The animals were weighed, …