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Year Number of Results
1997 1
2000 1
2001 1
2002 1
2004 1
2006 1
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2011 1
2014 1
2015 1
2022 1
2023 1
2024 0

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Page 1
2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC.
Authors/Task Force Members:; McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, Burri H, Butler J, Čelutkienė J, Chioncel O, Cleland JGF, Coats AJS, Crespo-Leiro MG, Farmakis D, Gilard M, Heymans S, Hoes AW, Jaarsma T, Jankowska EA, Lainscak M, Lam CSP, Lyon AR, McMurray JJV, Mebazaa A, Mindham R, Muneretto C, Francesco Piepoli M, Price S, Rosano GMC, Ruschitzka F, Kathrine Skibelund A; ESC Scientific Document Group. Authors/Task Force Members:, et al. Eur J Heart Fail. 2022 Jan;24(1):4-131. doi: 10.1002/ejhf.2333. Eur J Heart Fail. 2022. PMID: 35083827 Free article.
Lewis (Israel), Francisco Leyva (United Kingdom), AleVs Linhart (Czech Republic), Maja-Lisa Lochen (Norway), Lars H. Lund (Sweden), Donna Mancini (United States of America), Josep Masip (Spain), Davor Milicic (Croatia), Christian Mueller (Switzerland), Holger Nef (Germany) …
Lewis (Israel), Francisco Leyva (United Kingdom), AleVs Linhart (Czech Republic), Maja-Lisa Lochen (Norway), Lars H. Lund (Sweden), Donna …
Early Release Science of the exoplanet WASP-39b with JWST NIRCam.
Ahrer EM, Stevenson KB, Mansfield M, Moran SE, Brande J, Morello G, Murray CA, Nikolov NK, Petit Dit de la Roche DJM, Schlawin E, Wheatley PJ, Zieba S, Batalha NE, Damiano M, Goyal JM, Lendl M, Lothringer JD, Mukherjee S, Ohno K, Batalha NM, Battley MP, Bean JL, Beatty TG, Benneke B, Berta-Thompson ZK, Carter AL, Cubillos PE, Daylan T, Espinoza N, Gao P, Gibson NP, Gill S, Harrington J, Hu R, Kreidberg L, Lewis NK, Line MR, López-Morales M, Parmentier V, Powell DK, Sing DK, Tsai SM, Wakeford HR, Welbanks L, Alam MK, Alderson L, Allen NH, Anderson DR, Barstow JK, Bayliss D, Bell TJ, Blecic J, Bryant EM, Burleigh MR, Carone L, Casewell SL, Changeat Q, Chubb KL, Crossfield IJM, Crouzet N, Decin L, Désert JM, Feinstein AD, Flagg L, Fortney JJ, Gizis JE, Heng K, Iro N, Kempton EM, Kendrew S, Kirk J, Knutson HA, Komacek TD, Lagage PO, Leconte J, Lustig-Yaeger J, MacDonald RJ, Mancini L, May EM, Mayne NJ, Miguel Y, Mikal-Evans T, Molaverdikhani K, Palle E, Piaulet C, Rackham BV, Redfield S, Rogers LK, Roy PA, Rustamkulov Z, Shkolnik EL, Sotzen KS, Taylor J, Tremblin P, Tucker GS, Turner JD, de Val-Borro M, Venot O, Zhang X. Ahrer EM, et al. Nature. 2023 Feb;614(7949):653-658. doi: 10.1038/s41586-022-05590-4. Epub 2023 Jan 9. Nature. 2023. PMID: 36623551 Free PMC article.
The tumor suppressor hamartin enhances Dbl protein transforming activity through interaction with ezrin.
Ognibene M, Vanni C, Segalerba D, Mancini P, Merello E, Torrisi MR, Bosco MC, Varesio L, Eva A. Ognibene M, et al. J Biol Chem. 2011 Aug 26;286(34):29973-83. doi: 10.1074/jbc.M111.270785. Epub 2011 Jun 28. J Biol Chem. 2011. PMID: 21712385 Free PMC article.
In fact, the knock-down of ezrin and hamartin, as well as the expression of a mutant hamartin, unable to bind ezrin, inhibit Dbl transforming and exchange activity. These results suggest that Dbl is regulated by hamartin through association with ezrin....
In fact, the knock-down of ezrin and hamartin, as well as the expression of a mutant hamartin, unable to bind ezrin, inhibit Dbl transformin …
Identification of a novel mouse Dbl proto-oncogene splice variant: evidence that SEC14 domain is involved in GEF activity regulation.
Ognibene M, Vanni C, Blengio F, Segalerba D, Mancini P, De Marco P, Torrisi MR, Bosco MC, Varesio L, Eva A. Ognibene M, et al. Gene. 2014 Mar 10;537(2):220-9. doi: 10.1016/j.gene.2013.12.064. Epub 2014 Jan 9. Gene. 2014. PMID: 24412292
The N-terminal sequence of protoDbl contains negative regulatory elements that restrict the catalytic activity of the DH-PH module. Here, we report the identification of a new mouse protoDbl splice variant lacking exon 3. ...We show here that an altered SEC14 sequence lead …
The N-terminal sequence of protoDbl contains negative regulatory elements that restrict the catalytic activity of the DH-PH module. H …
Phosphorylation-independent membrane relocalization of ezrin following association with Dbl in vivo.
Vanni C, Parodi A, Mancini P, Visco V, Ottaviano C, Torrisi MR, Eva A. Vanni C, et al. Oncogene. 2004 May 20;23(23):4098-106. doi: 10.1038/sj.onc.1207509. Oncogene. 2004. PMID: 15064738
Finally, we show that the relocalization of ezrin is independent of Dbl GEF activity. These results indicate that Dbl could induce translocation of ezrin to the plasma membrane through a mechanism that does not require ezrin C-terminus phosphorylation by Rho-associated kin …
Finally, we show that the relocalization of ezrin is independent of Dbl GEF activity. These results indicate that Dbl could induce tr …
Modulation of oncogenic DBL activity by phosphoinositol phosphate binding to pleckstrin homology domain.
Russo C, Gao Y, Mancini P, Vanni C, Porotto M, Falasca M, Torrisi MR, Zheng Y, Eva A. Russo C, et al. J Biol Chem. 2001 Jun 1;276(22):19524-31. doi: 10.1074/jbc.M009742200. Epub 2001 Feb 26. J Biol Chem. 2001. PMID: 11278560 Free article.
We generated Dbl mutants unable to interact with PIPs. These mutants retained GEF activity on Cdc42 in the presence of PIPs and showed a markedly enhanced activating potential for both Cdc42 and RhoA in vivo while displaying decreased cellular transforming activity. …
We generated Dbl mutants unable to interact with PIPs. These mutants retained GEF activity on Cdc42 in the presence of PIPs and showe …
Distinct involvement of cdc42 and RhoA GTPases in actin organization and cell shape in untransformed and Dbl oncogene transformed NIH3T3 cells.
Olivo C, Vanni C, Mancini P, Silengo L, Torrisi MR, Tarone G, Defilippi P, Eva A. Olivo C, et al. Oncogene. 2000 Mar 9;19(11):1428-36. doi: 10.1038/sj.onc.1203440. Oncogene. 2000. PMID: 10723134
As a consequence of RhoA activation, Dbl-transformed cells show high activity of ROCK-alpha and CRIK kinases, two known RhoA effectors. ...
As a consequence of RhoA activation, Dbl-transformed cells show high activity of ROCK-alpha and CRIK kinases, two known RhoA effector …
Regulation of proto-Dbl by intracellular membrane targeting and protein stability.
Vanni C, Mancini P, Gao Y, Ottaviano C, Guo F, Salani B, Torrisi MR, Zheng Y, Eva A. Vanni C, et al. J Biol Chem. 2002 May 31;277(22):19745-53. doi: 10.1074/jbc.M111025200. Epub 2002 Mar 20. J Biol Chem. 2002. PMID: 11907027 Free article.
The pleckstrin homology (PH) domain of onco-Dbl, a guanine nucleotide exchange factor (GEF) for Cdc42 and RhoA GTPases, interacts with phosphoinositides (PIPs). This interaction modulates both the GEF activity and the targeting to the plasma membrane of onco-Dbl. Conversel …
The pleckstrin homology (PH) domain of onco-Dbl, a guanine nucleotide exchange factor (GEF) for Cdc42 and RhoA GTPases, interacts with phosp …
12 results