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The following term was not found in PubMed: Pszczolowski
Page 1
Paradoxical Embolism.
Hakman EN, Cowling KM. Hakman EN, et al. 2023 Sep 4. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Sep 4. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 29262019 Free Books & Documents.
Redirecting P450 EryK specificity by rational site-directed mutagenesis.
Montemiglio LC, Macone A, Ardiccioni C, Avella G, Vallone B, Savino C. Montemiglio LC, et al. Biochemistry. 2013 May 28;52(21):3678-87. doi: 10.1021/bi400223j. Epub 2013 May 16. Biochemistry. 2013. PMID: 23597312
The C-12 hydroxylase EryK is a bacterial cytochrome P450, active during one of the final tailoring steps of erythromycin A (ErA) biosynthesis. Its tight substrate specificity, restricted to the metabolic intermediate ErD, leads to the accumulation in the culture broth of a …
The C-12 hydroxylase EryK is a bacterial cytochrome P450, active during one of the final tailoring steps of erythromycin A (ErA) bios …
Azole drugs trap cytochrome P450 EryK in alternative conformational states.
Montemiglio LC, Gianni S, Vallone B, Savino C. Montemiglio LC, et al. Biochemistry. 2010 Nov 2;49(43):9199-206. doi: 10.1021/bi101062v. Biochemistry. 2010. PMID: 20845962
We report the crystal structures of EryK in complex with two widely used azole inhibitors: ketoconazole and clotrimazole. ...Nevertheless, because of the different chemical and structural properties of their N1-substituent group, ketoconazole and clotrimazole trap EryK …
We report the crystal structures of EryK in complex with two widely used azole inhibitors: ketoconazole and clotrimazole. ...Neverthe …
The role of erythromycin C-12 hydroxylase, EryK, as a substitute for PikC hydroxylase in pikromycin biosynthesis.
Lee SK, Basnet DB, Choi CY, Sohng JK, Ahn JS, Yoon YJ. Lee SK, et al. Bioorg Chem. 2004 Dec;32(6):549-59. doi: 10.1016/j.bioorg.2004.06.002. Bioorg Chem. 2004. PMID: 15530995
We have shown that EryK can accept the substrates of PikC from Streptomyces venezuelae which is responsible for the hydroxylation of YC-17 and narbomycin. ...Molecular modeling of the enzyme-substrate complex suggested the possible interaction of EryK with alternati …
We have shown that EryK can accept the substrates of PikC from Streptomyces venezuelae which is responsible for the hydroxylation of …
Overproduction and characterization of the erythromycin C-12 hydroxylase, EryK.
Lambalot RH, Cane DE, Aparicio JJ, Katz L. Lambalot RH, et al. Biochemistry. 1995 Feb 14;34(6):1858-66. doi: 10.1021/bi00006a006. Biochemistry. 1995. PMID: 7849045
A point of uncertainty in the erythromycin pathway has been whether the C-12 hydroxylase operates on each of two possible substrates, erythromycin B (ErB) and erythromycin D (ErD). Stassi et al. have cloned the gene, designated eryK, which encodes the P-450 monooxygenase r …
A point of uncertainty in the erythromycin pathway has been whether the C-12 hydroxylase operates on each of two possible substrates, erythr …
Knocking out of tailoring genes eryK and eryG in an industrial erythromycin-producing strain of Saccharopolyspora erythraea leading to overproduction of erythromycin B, C and D at different conversion ratios.
Zhang Q, Wu J, Qian J, Chu J, Zhuang Y, Zhang S, Liu W. Zhang Q, et al. Lett Appl Microbiol. 2011 Feb;52(2):129-37. doi: 10.1111/j.1472-765X.2010.02973.x. Epub 2010 Dec 22. Lett Appl Microbiol. 2011. PMID: 21175699
AIMS: To overproduce erythromycin C, B or D and evaluate the effect of disruption of tailoring genes eryK and eryG in an industrial erythromycin producer. METHODS AND RESULTS: The tailoring genes eryG and eryK were inactivated individually or simultaneously by targe …
AIMS: To overproduce erythromycin C, B or D and evaluate the effect of disruption of tailoring genes eryK and eryG in an industrial e …
Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea.
Gaisser S, Böhm GA, Cortés J, Leadlay PF. Gaisser S, et al. Mol Gen Genet. 1997 Oct;256(3):239-51. doi: 10.1007/s004380050566. Mol Gen Genet. 1997. PMID: 9393448
The gene cluster (ery) governing the biosynthesis of the macrolide antibiotic erythromycin A by Saccharopolyspora erythraea contains, in addition to the eryA genes encoding the polyketide synthase, two regions containing genes for later steps in the pathway. The region 5' of eryA …
The gene cluster (ery) governing the biosynthesis of the macrolide antibiotic erythromycin A by Saccharopolyspora erythraea contains, in add …
Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation.
Chen Y, Deng W, Wu J, Qian J, Chu J, Zhuang Y, Zhang S, Liu W. Chen Y, et al. Appl Environ Microbiol. 2008 Mar;74(6):1820-8. doi: 10.1128/AEM.02770-07. Epub 2008 Jan 25. Appl Environ Microbiol. 2008. PMID: 18223111 Free PMC article.
In this study, systematical modulation of the amounts of tailoring enzymes EryK (a P450 hydroxylase) and EryG (an S-adenosylmethionine-dependent O-methyltransferase) was carried out by genetic engineering in S. erythraea, including alterations of gene copy number ratio and …
In this study, systematical modulation of the amounts of tailoring enzymes EryK (a P450 hydroxylase) and EryG (an S-adenosylmethionin …
Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate.
Savino C, Montemiglio LC, Sciara G, Miele AE, Kendrew SG, Jemth P, Gianni S, Vallone B. Savino C, et al. J Biol Chem. 2009 Oct 16;284(42):29170-9. doi: 10.1074/jbc.M109.003590. Epub 2009 Jul 22. J Biol Chem. 2009. PMID: 19625248 Free PMC article.
In this work, we analyzed the three-dimensional structures of a monomeric cytochrome P450 from Saccharopolyspora erythraea, commonly called EryK, and the binding kinetics to its physiological ligand, erythromycin D. Three different structures of EryK were obtained: …
In this work, we analyzed the three-dimensional structures of a monomeric cytochrome P450 from Saccharopolyspora erythraea, commonly called …
29 results