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Showing results for promise varela
Search for Eromise Varela instead (3 results)
Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer.
Baselga J, Cortés J, Kim SB, Im SA, Hegg R, Im YH, Roman L, Pedrini JL, Pienkowski T, Knott A, Clark E, Benyunes MC, Ross G, Swain SM; CLEOPATRA Study Group. Baselga J, et al. N Engl J Med. 2012 Jan 12;366(2):109-19. doi: 10.1056/NEJMoa1113216. Epub 2011 Dec 7. N Engl J Med. 2012. PMID: 22149875 Free PMC article. Clinical Trial.
Pertuzumab, an anti-HER2 humanized monoclonal antibody that inhibits receptor dimerization, has a mechanism of action that is complementary to that of trastuzumab, and combination therapy with the two antibodies has shown promising activity and an acceptable safety profile …
Pertuzumab, an anti-HER2 humanized monoclonal antibody that inhibits receptor dimerization, has a mechanism of action that is complementary …
Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression.
González-Martínez I, Cerro-Herreros E, Moreno N, García-Rey A, Espinosa-Espinosa J, Carrascosa-Sàez M, Piqueras-Losilla D, Arzumanov A, Seoane-Miraz D, Jad Y, Raz R, Wood MJ, Varela MA, Llamusí B, Artero R. González-Martínez I, et al. Mol Ther Nucleic Acids. 2023 Sep 5;34:102024. doi: 10.1016/j.omtn.2023.09.001. eCollection 2023 Dec 12. Mol Ther Nucleic Acids. 2023. PMID: 37744174 Free PMC article.
Boosting the endogenous expression of MBNL proteins by inhibiting the natural translational repressors miR-23b and miR-218 has previously been shown to be a promising therapeutic approach. We designed antimiRs against both miRNAs with a phosphorodiamidate morpholino oligon …
Boosting the endogenous expression of MBNL proteins by inhibiting the natural translational repressors miR-23b and miR-218 has previously be …
Application of Antisense Conjugates for the Treatment of Myotonic Dystrophy Type 1.
Stoodley J, Vallejo-Bedia F, Seone-Miraz D, Debasa-Mouce M, Wood MJA, Varela MA. Stoodley J, et al. Int J Mol Sci. 2023 Jan 31;24(3):2697. doi: 10.3390/ijms24032697. Int J Mol Sci. 2023. PMID: 36769018 Free PMC article. Review.
With several antisense therapies currently in clinical trials, the outlook for achieving a clinically approved treatment for patients has never looked more promising....
With several antisense therapies currently in clinical trials, the outlook for achieving a clinically approved treatment for patients has ne …
Bacterial Metalo-Aminopeptidases as Targets in Human Infectious Diseases.
González-Bacerio J, Varela AC, Aguado ME, Izquierdo M, Méndez Y, Del Rivero MA, Rivera DG. González-Bacerio J, et al. Curr Drug Targets. 2022;23(12):1155-1190. doi: 10.2174/1389450123666220316085859. Curr Drug Targets. 2022. PMID: 35297344 Review.
For this reason, the identification of novel molecular targets and the discovery of new antibacterial compounds are urgently required. Metalo-aminopeptidases are promising targets in bacterial infections. They participate in crucial processes for bacterial growth and patho …
For this reason, the identification of novel molecular targets and the discovery of new antibacterial compounds are urgently required. Metal …
Phase organization of network computations.
Wilson MA, Varela C, Remondes M. Wilson MA, et al. Curr Opin Neurobiol. 2015 Apr;31:250-3. doi: 10.1016/j.conb.2014.12.011. Epub 2015 Feb 11. Curr Opin Neurobiol. 2015. PMID: 25679370 Free PMC article. Review.
This idea is supported by recent evidence, and newly developed techniques promise to put such theoretical framework to mechanistic testing. ...
This idea is supported by recent evidence, and newly developed techniques promise to put such theoretical framework to mechanistic te …
Electrical bioadhesive interface for bioelectronics.
Deng J, Yuk H, Wu J, Varela CE, Chen X, Roche ET, Guo CF, Zhao X. Deng J, et al. Nat Mater. 2021 Feb;20(2):229-236. doi: 10.1038/s41563-020-00814-2. Epub 2020 Sep 28. Nat Mater. 2021. PMID: 32989277
We demonstrate biocompatibility, applicability, mechanical and electrical stability, and recording and stimulation functionalities of the e-bioadhesive interface based on ex vivo porcine and in vivo rat models. These findings offer a promising strategy to improve tissue-de …
We demonstrate biocompatibility, applicability, mechanical and electrical stability, and recording and stimulation functionalities of the e- …
Non-heart-beating donation in Spain.
Gomez-de-Antonio D, Varela A. Gomez-de-Antonio D, et al. Gen Thorac Cardiovasc Surg. 2011 Jan;59(1):1-5. doi: 10.1007/s11748-010-0661-4. Epub 2011 Jan 12. Gen Thorac Cardiovasc Surg. 2011. PMID: 21225392 Review.
With this additional source of organs we have so far been able to perform 32 lung transplantations, which represents an increase of 13% of our annual transplantation rates. CONCLUSION: NHBD is no longer just a promising source of organs for lung transplantations, it is a r …
With this additional source of organs we have so far been able to perform 32 lung transplantations, which represents an increase of 13% of o …
DRAM1 Promotes Lysosomal Delivery of Mycobacterium marinum in Macrophages.
Banducci-Karp A, Xie J, Engels SAG, Sarantaris C, van Hage P, Varela M, Meijer AH, van der Vaart M. Banducci-Karp A, et al. Cells. 2023 Mar 7;12(6):828. doi: 10.3390/cells12060828. Cells. 2023. PMID: 36980169 Free PMC article.
Considering its prominent effect on host resistance to intracellular infection, DRAM1 is a promising target for therapeutic modulation of the microbicidal capacity of macrophages....
Considering its prominent effect on host resistance to intracellular infection, DRAM1 is a promising target for therapeutic modulatio …
Gene Therapy for High Grade Glioma: The Clinical Experience.
Varela ML, Comba A, Faisal SM, Argento A, Franson A, Barissi MN, Sachdev S, Castro MG, Lowenstein PR. Varela ML, et al. Expert Opin Biol Ther. 2023 Feb;23(2):145-161. doi: 10.1080/14712598.2022.2157718. Epub 2022 Dec 16. Expert Opin Biol Ther. 2023. PMID: 36510843 Free PMC article. Review.
This protocol remains unchanged since 2005, even though HGG median survival has marginally improved. AREAS COVERED: Gene therapy was developed as a promising approach to treat HGG. Here, we review completed and ongoing clinical trials employing viral and non-viral vectors …
This protocol remains unchanged since 2005, even though HGG median survival has marginally improved. AREAS COVERED: Gene therapy was develop …
Parasite Metalo-aminopeptidases as Targets in Human Infectious Diseases.
Aguado ME, Izquierdo M, González-Matos M, Varela AC, Méndez Y, Del Rivero MA, Rivera DG, González-Bacerio J. Aguado ME, et al. Curr Drug Targets. 2023;24(5):416-461. doi: 10.2174/1389450124666230224140724. Curr Drug Targets. 2023. PMID: 36825701 Review.
For this reason, the identification of novel molecular targets and the discovery of new chemotherapeutic agents are urgently required. Metalo- aminopeptidases are promising targets in parasitic infections. They participate in crucial processes for parasite growth and patho …
For this reason, the identification of novel molecular targets and the discovery of new chemotherapeutic agents are urgently required. Metal …
166 results