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Page 1
Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes.
Wagner A, Le TA, Brennich M, Klein P, Bader N, Diehl E, Paszek D, Weickhmann AK, Dirdjaja N, Krauth-Siegel RL, Engels B, Opatz T, Schindelin H, Hellmich UA. Wagner A, et al. Among authors: diehl e. Angew Chem Int Ed Engl. 2019 Mar 11;58(11):3640-3644. doi: 10.1002/anie.201810470. Epub 2019 Jan 30. Angew Chem Int Ed Engl. 2019. PMID: 30605929
Multiubiquitination of TRPV4 reduces channel activity independent of surface localization.
Aisenberg WH, McCray BA, Sullivan JM, Diehl E, DeVine LR, Alevy J, Bagnell AM, Carr P, Donohue JK, Goretzki B, Cole RN, Hellmich UA, Sumner CJ. Aisenberg WH, et al. Among authors: diehl e. J Biol Chem. 2022 Apr;298(4):101826. doi: 10.1016/j.jbc.2022.101826. Epub 2022 Mar 14. J Biol Chem. 2022. PMID: 35300980 Free PMC article.
PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression.
Dörsam B, Seiwert N, Foersch S, Stroh S, Nagel G, Begaliew D, Diehl E, Kraus A, McKeague M, Minneker V, Roukos V, Reißig S, Waisman A, Moehler M, Stier A, Mangerich A, Dantzer F, Kaina B, Fahrer J. Dörsam B, et al. Among authors: diehl e. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4061-E4070. doi: 10.1073/pnas.1712345115. Epub 2018 Apr 9. Proc Natl Acad Sci U S A. 2018. PMID: 29632181 Free PMC article.
Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies.
Jung S, Fuchs N, Johe P, Wagner A, Diehl E, Yuliani T, Zimmer C, Barthels F, Zimmermann RA, Klein P, Waigel W, Meyr J, Opatz T, Tenzer S, Distler U, Räder HJ, Kersten C, Engels B, Hellmich UA, Klein J, Schirmeister T. Jung S, et al. Among authors: diehl e. J Med Chem. 2021 Aug 26;64(16):12322-12358. doi: 10.1021/acs.jmedchem.1c01002. Epub 2021 Aug 11. J Med Chem. 2021. PMID: 34378914