A new index of ultrasonography for estimating cerebral circulation in newborn infants

J Med Ultrason (2001). 2020 Oct;47(4):635-640. doi: 10.1007/s10396-020-01041-7. Epub 2020 Jul 28.

Abstract

Purpose: To quantitatively estimate the influence of ductal shunt on cerebral blood flow and establish a new index of ultrasonography for estimating cerebral circulation without the influence of ductal shunt in newborn infants.

Methods: We retrospectively examined the records of anterior cerebral artery (ACA) and left pulmonary artery (LPA) blood flow velocity curves recorded by pulsed Doppler ultrasonography within 6 h after birth in 123 newborn infants without asphyxia (normal group) and in 31 newborn infants with asphyxia (asphyxia group).

Results: In the normal group, the resistance index (RI) of the ACA showed a positive correlation with the ratio of LPA diastolic-to-systolic flow velocities (LPAD/LPAS) (P < 0.001, r = 0.58), and the estimated RI (eRI) of the ACA was calculated using the following formula: Y = 0.47X + 0.67 (Y estimated RI; X LPAD/LPAS). In the asphyxia group, the RI of the ACA showed a weak correlation to base excess (BE) (P < 0.05, r = 0.46). The eRI of the ACA was calculated by the LPAD/PLAS in the asphyxia group, and the difference between the RI and eRI showed a better correlation to BE than RI (P < 0.001, r = 0.64).

Conclusion: We determined the relation between cerebral blood flow RI and ductal shunt, and (RI - eRI) may be a new useful ultrasonographic index indicating cerebral circulation without the influence of ductal shunt in newborn infants.

Keywords: Asphyxia; Cerebral blood flow; Ductal shunt; Newborn infant; Resistant index.

MeSH terms

  • Anterior Cerebral Artery / diagnostic imaging*
  • Anterior Cerebral Artery / physiopathology
  • Asphyxia Neonatorum / physiopathology*
  • Blood Flow Velocity
  • Cerebrovascular Circulation*
  • Ductus Arteriosus / abnormalities
  • Ductus Arteriosus / diagnostic imaging
  • Ductus Arteriosus / physiology
  • Female
  • Humans
  • Infant, Newborn
  • Male
  • Pulmonary Artery / diagnostic imaging*
  • Pulmonary Artery / physiopathology
  • Retrospective Studies
  • Ultrasonography, Doppler, Pulsed / methods*