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Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues.
Balla A, Auriola S, Grey AC, Demarais NJ, Valtari A, Heikkinen EM, Toropainen E, Urtti A, Vellonen KS, Ruponen M. Balla A, et al. Among authors: heikkinen em. Pharmaceutics. 2021 May 4;13(5):658. doi: 10.3390/pharmaceutics13050658. Pharmaceutics. 2021. PMID: 34064499 Free PMC article.
Esterase activity in porcine and albino rabbit ocular tissues.
Heikkinen EM, Del Amo EM, Ranta VP, Urtti A, Vellonen KS, Ruponen M. Heikkinen EM, et al. Eur J Pharm Sci. 2018 Oct 15;123:106-110. doi: 10.1016/j.ejps.2018.07.034. Epub 2018 Jul 17. Eur J Pharm Sci. 2018. PMID: 30030098 Free article.
Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: Tissue exposures in the rabbit eye.
Fayyaz A, Vellonen KS, Ranta VP, Toropainen E, Reinisalo M, Valtari A, Puranen J, Ricci GD, Heikkinen EM, Gardner I, Ruponen M, Urtti A, Jamei M, Del Amo EM. Fayyaz A, et al. Among authors: heikkinen em. Eur J Pharm Biopharm. 2021 Sep;166:155-162. doi: 10.1016/j.ejpb.2021.06.003. Epub 2021 Jun 15. Eur J Pharm Biopharm. 2021. PMID: 34139290 Free article.
Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics.
Heikkinen EM, Auriola S, Ranta VP, Demarais NJ, Grey AC, Del Amo EM, Toropainen E, Vellonen KS, Urtti A, Ruponen M. Heikkinen EM, et al. Mol Pharm. 2019 Sep 3;16(9):3968-3976. doi: 10.1021/acs.molpharmaceut.9b00585. Epub 2019 Aug 8. Mol Pharm. 2019. PMID: 31348666 Free PMC article.