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Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal.
Maji A, Soutar CP, Zhang J, Lewandowska A, Uno BE, Yan S, Shelke Y, Murhade G, Nimerovsky E, Borcik CG, Arango AS, Lange JD, Marin-Toledo JP, Lyu Y, Bailey KL, Roady PJ, Holler JT, Khandelwal A, SantaMaria AM, Sanchez H, Juvvadi PR, Johns G, Hageman MJ, Krise J, Gebremariam T, Youssef EG, Bartizal K, Marr KA, Steinbach WJ, Ibrahim AS, Patterson TF, Wiederhold NP, Andes DR, Pogorelov TV, Schwieters CD, Fan TM, Rienstra CM, Burke MD. Maji A, et al. Among authors: youssef eg. Nature. 2023 Nov;623(7989):1079-1085. doi: 10.1038/s41586-023-06710-4. Epub 2023 Nov 8. Nature. 2023. PMID: 37938782 Free PMC article.
Mucoricin is a ricin-like toxin that is critical for the pathogenesis of mucormycosis.
Soliman SSM, Baldin C, Gu Y, Singh S, Gebremariam T, Swidergall M, Alqarihi A, Youssef EG, Alkhazraji S, Pikoulas A, Perske C, Venkataramani V, Rich A, Bruno VM, Hotopp JD, Mantis NJ, Edwards JE Jr, Filler SG, Chamilos G, Vitetta ES, Ibrahim AS. Soliman SSM, et al. Among authors: youssef eg. Nat Microbiol. 2021 Mar;6(3):313-326. doi: 10.1038/s41564-020-00837-0. Epub 2021 Jan 18. Nat Microbiol. 2021. PMID: 33462434 Free PMC article.
Preserving Vascular Integrity Protects Mice against Multidrug-Resistant Gram-Negative Bacterial Infection.
Gebremariam T, Zhang L, Alkhazraji S, Gu Y, Youssef EG, Tong Z, Kish-Trier E, Bajji A, de Araujo CV, Rich B, French SW, Li DY, Mueller AL, Odelberg SJ, Zhu W, Ibrahim AS. Gebremariam T, et al. Among authors: youssef eg. Antimicrob Agents Chemother. 2020 Jul 22;64(8):e00303-20. doi: 10.1128/AAC.00303-20. Print 2020 Jul 22. Antimicrob Agents Chemother. 2020. PMID: 32393494 Free PMC article.
The Hyr1 protein from the fungus Candida albicans is a cross kingdom immunotherapeutic target for Acinetobacter bacterial infection.
Uppuluri P, Lin L, Alqarihi A, Luo G, Youssef EG, Alkhazraji S, Yount NY, Ibrahim BA, Bolaris MA, Edwards JE Jr, Swidergall M, Filler SG, Yeaman MR, Ibrahim AS. Uppuluri P, et al. Among authors: youssef eg. PLoS Pathog. 2018 May 10;14(5):e1007056. doi: 10.1371/journal.ppat.1007056. eCollection 2018 May. PLoS Pathog. 2018. PMID: 29746596 Free PMC article.