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Structural studies and biological evaluation of T30695 variants modified with single chiral glycerol-T reveal the importance of LEDGF/p75 for the aptamer anti-HIV-integrase activities.
Rivieccio E, Tartaglione L, Esposito V, Dell'Aversano C, Koneru PC, Scuotto M, Virgilio A, Mayol L, Kvaratskhelia M, Varra M. Rivieccio E, et al. Biochim Biophys Acta Gen Subj. 2019 Feb;1863(2):351-361. doi: 10.1016/j.bbagen.2018.11.001. Epub 2018 Nov 7. Biochim Biophys Acta Gen Subj. 2019. PMID: 30414444
Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative.
Scuotto M, Rivieccio E, Varone A, Corda D, Bucci M, Vellecco V, Cirino G, Virgilio A, Esposito V, Galeone A, Borbone N, Varra M, Mayol L. Scuotto M, et al. Among authors: rivieccio e. Nucleic Acids Res. 2015 Sep 18;43(16):7702-16. doi: 10.1093/nar/gkv789. Epub 2015 Aug 6. Nucleic Acids Res. 2015. PMID: 26250112 Free PMC article.