Stimulation and inhibition of respiratory burst in neutrophils as a result of action of weak combined magnetic fields adjusted to ICR of protonated water forms

Weak combined collinear magnetic fields (CMFs) composed of constant component, 60 μT and low-frequency alternating field, 100 nT, used in 40 min pretreatment, were shown to have diverse effects (alleviation/stimulation) depending on the frequency of the alternating component on respiratory burst intensity in neutrophil suspension after activation by N-formyl-Met-Leu-Phe recorded by luminol-dependent chemiluminescence. About 12.6 Hz frequency formally corresponding to ion cyclotron resonance (ICR) frequency of hydrated hydronium ion (Н₉О₄ ⁺) had notable stimulating effect. On the contrary, treatment with 48.5 Hz frequency corresponding to hydronium ion (Н₃О⁺) was accompanied by significant alleviation of respiratory burst intensity. CMFs-pretreated water conducted only stimulating effect of CMFs when the field was adjusted to ICR of hydrated hydronium ion form, which is direct proof of participation of water in the mechanism of this effect of CMFs.